[Comparative study of the behavior of isoflurane and halothane in pediatric anesthesia]. 1992

F Díaz, and M Castilla, and M I Fernández, and J E Caballero
Sección de Anestesia Pediátrica, Hospital Materno-Infantil, Málaga.

This study involves 60 patients below the age of 14 years who were subjected to short duration surgical procedures under inhalation anesthesia with halothane and isoflurane at equivalent CAM in 50% protoxide. The objectives of the study were: a) to establish which of the two inhalational agents produced the more rapid anesthetic induction; b) to determine which exerted the more marked potentiation of the neuromuscular blockade induced by succinylcholine, and c) to compare the anesthetic quality during the induction and recovery periods of both halogenated agents. Induction was more rapid after halothane (mean induction time of 2.91 +/- 0.97 min) than after isoflurane (mean induction time of 6.24 +/- 2.88 min; p less than 0.001). Potentiation of succinylcholine induced neuromuscular blockade was greater after isoflurane than after halothane: the mean time of apnea was 4.56 +/- 1.82 min for isoflurane and 3.41 +/- 1.63 min for halothane (p less than 0.05). Undesirable effects were larger in patients treated with isoflurane than in patients anesthetized with halothane (mean score: 12.60 +/- 3.53 points vs 14.41 +/- 2.33 points; p less than 0.001). The analysis of anesthetic quality during the recovery period gave a mean punctuation of 16.62 +/- 2.21 to patients treated with halothane, whereas patients anesthetized with isoflurane showed a lower score of 14.25 +/- 1.99 points (p less than 0.001). The higher scores corresponded to the most well tolerated anesthetic induction and recovery. The highest attainable score in this study was 18.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D007530 Isoflurane A stable, non-explosive inhalation anesthetic, relatively free from significant side effects.
D008297 Male Males
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D002675 Child, Preschool A child between the ages of 2 and 5. Children, Preschool,Preschool Child,Preschool Children
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug
D005260 Female Females
D006221 Halothane A nonflammable, halogenated, hydrocarbon anesthetic that provides relatively rapid induction with little or no excitement. Analgesia may not be adequate. NITROUS OXIDE is often given concomitantly. Because halothane may not produce sufficient muscle relaxation, supplemental neuromuscular blocking agents may be required. (From AMA Drug Evaluations Annual, 1994, p178) 1,1,1-Trifluoro-2-Chloro-2-Bromoethane,Fluothane,Ftorotan,Narcotan
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

Related Publications

F Díaz, and M Castilla, and M I Fernández, and J E Caballero
February 1986, Anesthesia and analgesia,
F Díaz, and M Castilla, and M I Fernández, and J E Caballero
January 1992, Revista espanola de anestesiologia y reanimacion,
F Díaz, and M Castilla, and M I Fernández, and J E Caballero
March 1990, Minerva anestesiologica,
F Díaz, and M Castilla, and M I Fernández, and J E Caballero
January 1987, Revista espanola de anestesiologia y reanimacion,
F Díaz, and M Castilla, and M I Fernández, and J E Caballero
March 1986, Ma zui xue za zhi = Anaesthesiologica Sinica,
F Díaz, and M Castilla, and M I Fernández, and J E Caballero
September 1990, Minerva anestesiologica,
F Díaz, and M Castilla, and M I Fernández, and J E Caballero
January 1988, Minerva anestesiologica,
F Díaz, and M Castilla, and M I Fernández, and J E Caballero
February 1988, Anesthesiology,
F Díaz, and M Castilla, and M I Fernández, and J E Caballero
January 1987, Revista espanola de anestesiologia y reanimacion,
F Díaz, and M Castilla, and M I Fernández, and J E Caballero
October 1989, Anesthesia and analgesia,
Copied contents to your clipboard!