Induction of labour with oral misoprostol for prelabour rupture of membranes at term. 2005

Jehan Ara, and Meher Noorani
Department of Obstetrics and Gynaecology, Unit 1, Dow University of Health Sciences and Civil Hospital, Karachi.

OBJECTIVE To study the efficacy, safety and maternal satisfaction of oral misoprostol for induction of labour in patients with prelabour rupture of membrane at term (PROM). METHODS Pregnant women with singleton pregnancy at term with cephalic presentation with prelabour rupture of membranes having no other obstetric and maternal contraindications for induction of labour, were included in the study. Patients were given 50ugm of oral misoprostol at six hourly intervals for a total of three doses or until labour was established. RESULTS Of the 104 patients included in the study, 28 (26.9%) were primigraivda and 72.1% were multigravida. Induction delivery internal was shorter in multigravida and longer in primigraivda. Patients with Bishop score of less than 5 had a longer induction delivery interval as compared to patients with Bishop score more than 5. Significant side effects included nausea and vomiting in 68 patients (65.3%). Vaginal delivery was achieved in 80.7% with Cesarean section in 19.2% of patients. Neonatal outcome was good with no stillbirths and only two neonatal deaths. A large number, 98 (94.2%) of women were satisfied with induction of labour with oral misoprostol in PROM. CONCLUSIONS Active management with oral misoprostol resulted in more women going into labour and delivering within 24 hours of PROM with no significant maternal and neonatal complications.

UI MeSH Term Description Entries
D007231 Infant, Newborn An infant during the first 28 days after birth. Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D007751 Labor, Induced Artificially induced UTERINE CONTRACTION. Induced Labor,Induction of Labor,Labor Induced,Labor Induction,Induced, Labor,Induction, Labor,Inductions, Labor,Labor Inductions
D011247 Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH. Gestation,Pregnancies
D011256 Pregnancy Outcome Results of conception and ensuing pregnancy, including LIVE BIRTH; STILLBIRTH; or SPONTANEOUS ABORTION. The outcome may follow natural or artificial insemination or any of the various ASSISTED REPRODUCTIVE TECHNIQUES, such as EMBRYO TRANSFER or FERTILIZATION IN VITRO. Outcome, Pregnancy,Outcomes, Pregnancy,Pregnancy Outcomes
D005260 Female Females
D005322 Fetal Membranes, Premature Rupture Spontaneous tearing of the membranes surrounding the FETUS any time before the onset of OBSTETRIC LABOR. Preterm PROM is membrane rupture before 37 weeks of GESTATION. Premature Rupture of Membrane (Pregnancy),PROM (Pregnancy),Premature Rupture of Fetal Membranes,Preterm PROM (Pregnancy),Preterm Premature Rupture of Fetal Membranes,Membrane Premature Rupture (Pregnancy),Membrane Premature Ruptures (Pregnancy),PROM, Preterm (Pregnancy)
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D012449 Safety Freedom from exposure to danger and protection from the occurrence or risk of injury or loss. It suggests optimal precautions in the workplace, on the street, in the home, etc., and includes personal safety as well as the safety of property. Safeties
D016595 Misoprostol A synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties. Apo-Misoprostol,Cytotec,Glefos,Misoprostol, (11alpha,13E)-Isomer,Misoprostol, (11alpha,13E,16R)-Isomer,Misoprostol, (11alpha,13Z)-(+-)-Isomer,Misoprostol, (11alpha.13E,16S)-Isomer,Misoprostol, (11beta,13E)-(+-)-Isomer,Misoprostol, (11beta,13E,16R)-Isomer,Misoprostol, (11beta,13E,16S)-Isomer,Novo-Misoprostol,SC-29333,SC-30249,Apo Misoprostol,Novo Misoprostol,SC 29333,SC 30249,SC29333,SC30249

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