Endothelin-1 levels in plasma and cerebrospinal fluid of patients with cerebral vasospasm after aneurysmal subarachnoid hemorrhage. 2005

Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
Neurosurgical Service, Medical School, University of Brasilia, 71680-070 Brasília-DF, Brazil.

BACKGROUND Plasma and cerebrospinal fluid (CSF) concentrations of endothelin-1 (ET-1) were measured in patients with subarachnoid hemorrhage (SAH) after aneurysmal rupture and compared with levels of ET-1 in volunteers. We analyze the relationship between levels of ET-1 in both CSF and plasma with the risk of developing cerebral vasospasm (CVS). METHODS Cerebrospinal fluid and blood samples were collected from 30 selected patients after SAH and from 10 healthy volunteers who were used as control. All samples were stored at -70 degrees C and the levels of ET-1 in CSF and blood were measured by using enzyme-linked immunosorbent assay and Western blot. All patients were submitted to angiography to confirm vasospasm. RESULTS From the 30 patients admitted at different days of SAH, 18 (60%) developed clinical CVS and 10 (33%) presented angiographic CVS. The levels of ET-1 in the CSF were significantly higher (P = .0001) in patients (1.618 +/- 1.05 fmol/mL) than in controls (0.365 +/- 0.328 fmol/mL). There was statistical difference (P < .05) in CSF levels of ET-1 between each group of the Hunt-Hess scale and controls. The mean plasma concentration of ET-1 was similar (P > .05) in the control group (1.531 +/- 0.753 fmol/mL) and in patients with SAH (1.920 +/- 1.15 fmol/mL). CONCLUSIONS These findings indicate that a significant rise in ET-1 levels in the CSF, but not in the plasma, occurs in patients who develop CVS after SAH. Our observation suggests that ET-1 might be involved in the pathogenesis of SAH-associated CVS.

UI MeSH Term Description Entries
D011237 Predictive Value of Tests In screening and diagnostic tests, the probability that a person with a positive test is a true positive (i.e., has the disease), is referred to as the predictive value of a positive test; whereas, the predictive value of a negative test is the probability that the person with a negative test does not have the disease. Predictive value is related to the sensitivity and specificity of the test. Negative Predictive Value,Positive Predictive Value,Predictive Value Of Test,Predictive Values Of Tests,Negative Predictive Values,Positive Predictive Values,Predictive Value, Negative,Predictive Value, Positive
D012016 Reference Values The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality. Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D002533 Cerebral Angiography Radiography of the vascular system of the brain after injection of a contrast medium. Angiography, Cerebral,Angiographies, Cerebral,Cerebral Angiographies
D002536 Cerebral Arteries The arterial blood vessels supplying the CEREBRUM. Arteries, Cerebral,Artery, Cerebral,Cerebral Artery
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor
D013345 Subarachnoid Hemorrhage Bleeding into the intracranial or spinal SUBARACHNOID SPACE, most resulting from INTRACRANIAL ANEURYSM rupture. It can occur after traumatic injuries (SUBARACHNOID HEMORRHAGE, TRAUMATIC). Clinical features include HEADACHE; NAUSEA; VOMITING, nuchal rigidity, variable neurological deficits and reduced mental status. Hemorrhage, Subarachnoid,Perinatal Subarachnoid Hemorrhage,Subarachnoid Hemorrhage, Aneurysmal,Subarachnoid Hemorrhage, Spontaneous,SAH (Subarachnoid Hemorrhage),Subarachnoid Hemorrhage, Intracranial,Aneurysmal Subarachnoid Hemorrhage,Aneurysmal Subarachnoid Hemorrhages,Hemorrhage, Aneurysmal Subarachnoid,Hemorrhage, Intracranial Subarachnoid,Hemorrhage, Perinatal Subarachnoid,Hemorrhage, Spontaneous Subarachnoid,Hemorrhages, Aneurysmal Subarachnoid,Hemorrhages, Intracranial Subarachnoid,Hemorrhages, Perinatal Subarachnoid,Hemorrhages, Spontaneous Subarachnoid,Hemorrhages, Subarachnoid,Intracranial Subarachnoid Hemorrhage,Intracranial Subarachnoid Hemorrhages,Perinatal Subarachnoid Hemorrhages,SAHs (Subarachnoid Hemorrhage),Spontaneous Subarachnoid Hemorrhage,Spontaneous Subarachnoid Hemorrhages,Subarachnoid Hemorrhage, Perinatal,Subarachnoid Hemorrhages,Subarachnoid Hemorrhages, Aneurysmal,Subarachnoid Hemorrhages, Intracranial,Subarachnoid Hemorrhages, Perinatal,Subarachnoid Hemorrhages, Spontaneous
D013346 Subarachnoid Space The space between the arachnoid membrane and PIA MATER, filled with CEREBROSPINAL FLUID. It contains large blood vessels that supply the BRAIN and SPINAL CORD. Space, Subarachnoid,Spaces, Subarachnoid,Subarachnoid Spaces
D015854 Up-Regulation A positive regulatory effect on physiological processes at the molecular, cellular, or systemic level. At the molecular level, the major regulatory sites include membrane receptors, genes (GENE EXPRESSION REGULATION), mRNAs (RNA, MESSENGER), and proteins. Receptor Up-Regulation,Upregulation,Up-Regulation (Physiology),Up Regulation
D019332 Endothelin-1 A 21-amino acid peptide produced in a variety of tissues including endothelial and vascular smooth-muscle cells, neurons and astrocytes in the central nervous system, and endometrial cells. It acts as a modulator of vasomotor tone, cell proliferation, and hormone production. (N Eng J Med 1995;333(6):356-63) Big Endothelin,Big Endothelin-1,Endothelin Type 1,Endothelin, Big,Preproendothelin,Preproendothelin-1,Proendothelin (1-38),Proendothelin-1 Precursor,Big Endothelin 1,Endothelin 1,Endothelin-1, Big,Precursor, Proendothelin-1,Preproendothelin 1,Proendothelin 1 Precursor

Related Publications

Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
October 2011, Journal of neurosurgical anesthesiology,
Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
March 2015, Biological research for nursing,
Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
July 2016, Medical science monitor : international medical journal of experimental and clinical research,
Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
July 1994, Acta anaesthesiologica Scandinavica,
Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
May 2001, Stroke,
Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
December 2000, Stroke,
Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
August 2020, Neurocritical care,
Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
February 2000, Surgical neurology,
Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
February 2014, Neurocritical care,
Iruena Moraes Kessler, and Yolanda Galindo Pacheco, and Silene Paulino Lozzi, and Antônio Santos de Araújo, and Franz Jooji Onishi, and Paulo Andrade de Mello
January 1991, Life sciences,
Copied contents to your clipboard!