Biomaterial Database

Experimental reproduction of porcine proliferative enteritis. 1992

M R Alderton, and R Borland, and P J Coloe

Department of Applied Biology, Victoria University of Technology, Melbourne, Australia.

A campylobacter-like bacterium, isolated from the terminal ileum of a pig with porcine proliferative enteritis (PPE), was used to initiate PPE in healthy crossbred pigs. Post-mortem examinations of pigs infected orally with the bacterium revealed thickening of the terminal ileum, haemorrhage within the ileum, degeneration of ileal villi and large quantities of bile and mucous in the ileal contents. Histopathological examination revealed that the terminal ileum, ileo-caecal valve and caecum from infected pigs had partial or total loss of mucous membrane, hyperplasia of the crypt and glandular epithelial cells, campylobacter-like organisms in and around the Peyers' patches and lymphoid aggregates in the mucosa. The causative organism was re-isolated from the intestinal specimens of infected animals post-mortem. In control animals, kept under the same conditions, no evidence of abnormality was observed in the terminal ileum, ileo-caecal valve or caecum.

UI	MeSH Term	Description	Entries
D007080	Ileocecal Valve	The valve, at the junction of the CECUM with the COLON, that guards the opening where the ILEUM enters the LARGE INTESTINE.	Ileocecal Valves,Valve, Ileocecal,Valves, Ileocecal
D007082	Ileum	The distal and narrowest portion of the SMALL INTESTINE, between the JEJUNUM and the ILEOCECAL VALVE of the LARGE INTESTINE.
D010581	Peyer's Patches	Lymphoid tissue on the mucosa of the small intestine.	Patches, Peyer's,Peyer Patches,Peyers Patches
D002169	Campylobacter Infections	Infections with bacteria of the genus CAMPYLOBACTER.	Campylobacter Infection,Campylobacteriosis,Infections, Campylobacter,Campylobacterioses,Infection, Campylobacter
D002432	Cecum	The blind sac or outpouching area of the LARGE INTESTINE that is below the entrance of the SMALL INTESTINE. It has a worm-like extension, the vermiform APPENDIX.	Cecums
D004751	Enteritis	Inflammation of any segment of the SMALL INTESTINE.	Enteritides
D006471	Gastrointestinal Hemorrhage	Bleeding in any segment of the GASTROINTESTINAL TRACT from ESOPHAGUS to RECTUM.	Hematochezia,Hemorrhage, Gastrointestinal,Gastrointestinal Hemorrhages,Hematochezias
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013552	Swine	Any of various animals that constitute the family Suidae and comprise stout-bodied, short-legged omnivorous mammals with thick skin, usually covered with coarse bristles, a rather long mobile snout, and small tail. Included are the genera Babyrousa, Phacochoerus (wart hogs), and Sus, the latter containing the domestic pig (see SUS SCROFA).	Phacochoerus,Pigs,Suidae,Warthogs,Wart Hogs,Hog, Wart,Hogs, Wart,Wart Hog
D013553	Swine Diseases	Diseases of domestic swine and of the wild boar of the genus Sus.	Disease, Swine,Diseases, Swine,Swine Disease