Biomaterial Database

Secondary autoimmune diseases in herpes gestationis (pemphigoid gestationis). 1992

J K Shornick, and M M Black

University of Connecticut Health Center, Farmington.

BACKGROUND Herpes gestationis (HG) is an autoimmune disease of the skin that occurs exclusively in association with pregnancy (or trophoblastic disease). It is associated with the HLA-DR3 and -DR4 antigens that are also associated with several other autoimmune diseases. HG has previously been reported in association with Graves' disease. OBJECTIVE Our purpose was to determine the frequency of other autoimmune disease(s) in patients with a history of HG. METHODS Seventy-five patients with a history of HG were studied for the frequency of other autoimmune diseases. RESULTS We found an increased frequency of Graves' disease in patients with a history of HG. Those with HG have an increased risk for the development of other autoantibodies. There is an increased frequency of autoimmune diseases in the family members of patients with HG. CONCLUSIONS Secondary autoimmune disease in HG is unusual, but does occur. The most frequent is Graves' disease.

UI	MeSH Term	Description	Entries
D011247	Pregnancy	The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	Gestation,Pregnancies
D005190	Family	A social group consisting of parents or parent substitutes and children.	Family Life Cycles,Family Members,Family Life Cycle,Family Research,Filiation,Kinship Networks,Relatives,Families,Family Member,Kinship Network,Life Cycle, Family,Life Cycles, Family,Network, Kinship,Networks, Kinship,Research, Family
D005260	Female		Females
D006111	Graves Disease	A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).	Basedow's Disease,Exophthalmic Goiter,Goiter, Exophthalmic,Graves' Disease,Basedow Disease,Hyperthyroidism, Autoimmune,Basedows Disease,Disease, Basedow,Disease, Basedow's,Disease, Graves,Disease, Graves',Exophthalmic Goiters,Goiters, Exophthalmic
D006559	Pemphigoid Gestationis	An itching, autoimmune, bullous SKIN disease that occurs during the last two trimesters of PREGNANCY and PUERPERIUM. It also affects non-pregnant females with tissue of PLACENTA origin, such as CHORIOCARCINOMA; or HYDATIDIFORM MOLE. It exhibits antigenic and clinical similarity to bullous pemphigoid (PEMPHIGOID, BULLOUS). This disease does not involve herpes viruses (old name, herpes gestationis).	Gestational Pemphigoid,Herpes Gestationis,Gestational Pemphigoids,Gestationi, Pemphigoid,Gestationis, Pemphigoid,Pemphigoid Gestationi,Pemphigoid, Gestational,Pemphigoids, Gestational
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D001323	Autoantibodies	Antibodies that react with self-antigens (AUTOANTIGENS) of the organism that produced them.	Autoantibody
D001327	Autoimmune Diseases	Disorders that are characterized by the production of antibodies that react with host tissues or immune effector cells that are autoreactive to endogenous peptides.	Autoimmune Disease,Disease, Autoimmune,Diseases, Autoimmune
D015803	HLA-DR3 Antigen	An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*03 alleles.	HLA-DR3,Antigen, HLA-DR3,HLA DR3 Antigen
D015804	HLA-DR4 Antigen	An HLA-DR antigen which is associated with HLA-DRB1 CHAINS encoded by DRB1*04 alleles.	HLA-DR4,Antigen, HLA-DR4,HLA DR4 Antigen