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Synthesis and degradation of nucleic Acid components by formamide and cosmic dust analogues. 2005
Raffaele Saladino, and
Claudia Crestini, and
Veronica Neri, and
John R Brucato, and
Luigi Colangeli, and
Fabiana Ciciriello, and
Ernesto Di Mauro, and
Giovanna Costanzo
Dipartimento A.B.A.C., Università della Tuscia, Via San Camillo De Lellis, 01100 Viterbo, Italy. saladino@unitus.it
We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formamide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.
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