Reverse Osmosis is finding increasing use for the treatment of municipal and industrial wastewaters due to the growing demand for high quality water in large urban areas. The growing success of membranes in this application is related to improved process designs and improved membrane products. Key factors which have been determined to result in successful operation of large-scale plants will be discussed. Factors which play a key role in the use of RO membranes include ultra or microfiltration pretreatment, low fouling membranes, flux rate, recovery and control of fouling and scaling. In particular, high flux rates can be used when UF or MF pretreatment is used. These technologies remove most of the suspended particles that would normally cause heavy fouling of lead elements. Typically, fluxes in the range of 17-21 lmh lead to cleaning frequencies in the range of 3-4 months. By combining the use of membrane pretreatment and chloramination of the feed water through chlorine addition, two of the primary sources of RO membrane fouling can be controlled. The use of chloramine has become a proven means to control biofouling in a membrane for wastewater applications. The other significant problems for RO membranes result from organics fouling by dissolved organics and scaling due to saturation of marginally soluble salts. The former can be a significant problem for membranes, due to the strong attraction forces. To some extent, these can be mitigated by making the membrane surface more hydrophilic or changing the charge of the membrane surface. To minimize fouling, many plants are turning to low fouling membranes. Extensive studies have demonstrated that the membrane surface is hydrophilic, neutrally charged over a broad pH range, and more resistant to organic adsorption. Also, an analysis of the potential scaling issues will be reviewed. In particular, calcium phosphate has been found to be one of the key scalants that will limit RO system recovery rate. Calcium phosphate concentrations can reach high values in many wastewaters, and scaling of this compound is not often modeled in most RO projection software. Various process options will be presented to evaluate the most economic means of avoiding phosphate scaling. Finally, data from major RO wastewater treatment plants will be presented to show how the RO membranes operate under actual conditions, utilizing many of these design features. Long-term data from the 2.6 mgd Bedok demonstration Plant demonstrate that the RO membranes operate consistently on wastewater. Experiences from the 8.5 mgd (32,000 m3/day) Bedok and 10.5 mgd (40,000 m3/day) Kranji plants will also be presented. These large plants started operation in the fall of 2002 and have demonstrated an effective means to reclaim high quality water from difficult source waters, such as municipal wastewaters.