BACKGROUND In Denmark, outpatient laparoscopic cholecystectomy (LC) has been evaluated only in small studies. METHODS The first 300 consecutive patients undergoing LC in a university hospital outpatient clinic were evaluated prospectively. Complications, lack of same-day discharge (SDD), postoperative symptoms, and possibilities for training were recorded. RESULTS The median length of surgery was 65 minutes. The conversion rate was 4%. The SDD failure rate was 23%. The percentage of readmissions was 5%. The mortality rate was 0%. Blood transfusions were given in two cases. Two umbilical port sites were infected and needed surgical drainage. No major bile duct injury occurred. Two cystic duct lesions and two small bile leaks from the gallbladder bed were diagnosed and treated. LCs" being performed by junior residents had no influence on the perioperative risks. CONCLUSIONS Outpatient LC is safe when performed by trainees under supervision.