Biomaterial Database

[Treatment of uncontrollable, life-threatening hemorrhage]. 2005

Jakob Stensballe, and Stefan Lethagen, and Pär Ingemar Johansson

Anaestesi- og operationsklinikken 4231/TraumeCentret, H:S Rigshospitalet, DK-2100 København Ø. jakob.stensballe@rh.hosp.dk

A severely injured patient was treated for uncontrollable, life-threatening haemorrhage according to a new standardised algorithm at Rigshospitalet, Copenhagen University Hospital. Despite aggressive surgical treatment, the diffuse bleeding continued and treatment with an ''emergency transfusion package'' (5 units of red blood cells plus 5 units of fresh-frozen plasma plus 2 units of platelets) with a subsequent infusion of fibrinogen plus a single dose of 100 microg/kg recombinant factor VIIa was initiated. Haemostasis was achieved, and the patient recovered with a good clinical outcome.

UI	MeSH Term	Description	Entries
D009104	Multiple Trauma	Multiple physical insults or injuries occurring simultaneously.	Injuries, Multiple,Trauma, Multiple,Wounds, Multiple,Multiple Injuries,Polytrauma,Injury, Multiple,Multiple Injury,Multiple Traumas,Multiple Wound,Multiple Wounds,Polytraumas,Traumas, Multiple,Wound, Multiple
D001803	Blood Transfusion	The introduction of whole blood or blood component directly into the blood stream. (Dorland, 27th ed)	Blood Transfusions,Transfusion, Blood,Transfusions, Blood
D003029	Coagulants	Agents that cause clotting.	Coagulant
D005260	Female		Females
D006470	Hemorrhage	Bleeding or escape of blood from a vessel.	Bleeding,Hemorrhages
D006490	Hemostatics	Agents acting to arrest the flow of blood. Absorbable hemostatics arrest bleeding either by the formation of an artificial clot or by providing a mechanical matrix that facilitates clotting when applied directly to the bleeding surface. These agents function more at the capillary level and are not effective at stemming arterial or venous bleeding under any significant intravascular pressure.	Antihemorrhagic,Hemostatic,Antihemorrhagics
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328	Adult	A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available.	Adults
D015942	Factor VIIa	Activated form of factor VII. Factor VIIa activates factor X in the extrinsic pathway of blood coagulation.	Coagulation Factor VIIa,Factor VII, Activated,Blood Coagulation Factor VII, Activated,Factor 7A,Factor Seven A,Activated Factor VII,Factor VIIa, Coagulation
D016896	Treatment Outcome	Evaluation undertaken to assess the results or consequences of management and procedures used in combating disease in order to determine the efficacy, effectiveness, safety, and practicability of these interventions in individual cases or series.	Rehabilitation Outcome,Treatment Effectiveness,Clinical Effectiveness,Clinical Efficacy,Patient-Relevant Outcome,Treatment Efficacy,Effectiveness, Clinical,Effectiveness, Treatment,Efficacy, Clinical,Efficacy, Treatment,Outcome, Patient-Relevant,Outcome, Rehabilitation,Outcome, Treatment,Outcomes, Patient-Relevant,Patient Relevant Outcome,Patient-Relevant Outcomes