Cross-reactivity of IgM and IgG anticardiolipin antibodies with oxidized-low density lipoproteins. 2005

J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
Department of Clinical and Experimental Immunology, University Hospital Maastricht, P. O. Box 5800, 6202 AZ Maastricht, the Netherlands. jdam@limm.azm.nl

Anticardiolipin antibodies (aCLAs) and antibodies to oxidized-low density lipoproteins (oxLDL) are associated with two distinct diseases: the antiphospholipid syndrome and atherosclerosis. Because both diseases may be apparent in patients with systemic lupus erythematosus (SLE), it is important to establish the relationship between these two types of antibodies. In the present study, we examined whether sera containing IgM and/or IgG aCLAs also react with LDL that has been oxidized by conjugation with malondialdehyde (MDA-LDL) or by incubation with copper ions (Cu-LDL). Results revealed a clear correlation between IgM aCLAs and IgM anti-MDA-LDL antibodies, and a weak correlation between IgG aCLAs and IgG anti-Cu-LDL antibodies. Cross-reactivity between both antibodies seemed to be limited. Because aCLAs are heterogeneous, only a minor subset of these antibodies may cross-react with oxLDL. Therefore, identification of both antibodies may be relevant for determination of the prognosis of accelerated atherosclerosis in SLE patients.

UI MeSH Term Description Entries
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007075 Immunoglobulin M A class of immunoglobulin bearing mu chains (IMMUNOGLOBULIN MU-CHAINS). IgM can fix COMPLEMENT. The name comes from its high molecular weight and originally was called a macroglobulin. Gamma Globulin, 19S,IgM,IgM Antibody,IgM1,IgM2,19S Gamma Globulin,Antibody, IgM
D008077 Lipoproteins, LDL A class of lipoproteins of small size (18-25 nm) and light (1.019-1.063 g/ml) particles with a core composed mainly of CHOLESTEROL ESTERS and smaller amounts of TRIGLYCERIDES. The surface monolayer consists mostly of PHOSPHOLIPIDS, a single copy of APOLIPOPROTEIN B-100, and free cholesterol molecules. The main LDL function is to transport cholesterol and cholesterol esters to extrahepatic tissues. Low-Density Lipoprotein,Low-Density Lipoproteins,beta-Lipoprotein,beta-Lipoproteins,LDL(1),LDL(2),LDL-1,LDL-2,LDL1,LDL2,Low-Density Lipoprotein 1,Low-Density Lipoprotein 2,LDL Lipoproteins,Lipoprotein, Low-Density,Lipoproteins, Low-Density,Low Density Lipoprotein,Low Density Lipoprotein 1,Low Density Lipoprotein 2,Low Density Lipoproteins,beta Lipoprotein,beta Lipoproteins
D008180 Lupus Erythematosus, Systemic A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008315 Malondialdehyde The dialdehyde of malonic acid. Malonaldehyde,Propanedial,Malonylaldehyde,Malonyldialdehyde,Sodium Malondialdehyde,Malondialdehyde, Sodium
D010084 Oxidation-Reduction A chemical reaction in which an electron is transferred from one molecule to another. The electron-donating molecule is the reducing agent or reductant; the electron-accepting molecule is the oxidizing agent or oxidant. Reducing and oxidizing agents function as conjugate reductant-oxidant pairs or redox pairs (Lehninger, Principles of Biochemistry, 1982, p471). Redox,Oxidation Reduction
D003300 Copper A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55. Copper-63,Copper 63
D003429 Cross Reactions Serological reactions in which an antiserum against one antigen reacts with a non-identical but closely related antigen. Cross Reaction,Reaction, Cross,Reactions, Cross
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man

Related Publications

J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
November 2001, Infection and immunity,
J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
March 2014, BMC infectious diseases,
J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
January 2015, Gastroenterology research and practice,
J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
March 1990, Acta neurologica Scandinavica,
J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
January 1988, The Journal of rheumatology,
J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
June 1995, Clinica chimica acta; international journal of clinical chemistry,
J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
January 2002, Physiological research,
J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
April 2001, Rheumatology (Oxford, England),
J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
November 1983, Journal of lipid research,
J Damoiseaux, and A D Jeyasekharan, and R Theunissen, and J W Cohen Tervaert
August 2004, Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. Purkyne,
Copied contents to your clipboard!