Cancer chemopreventive effects of Pinus Maritima bark extract on ultraviolet radiation and ultraviolet radiation-7,12,dimethylbenz(a)anthracene induced skin carcinogenesis of hairless mice. 2006

Maria Kyriazi, and Dido Yova, and Michail Rallis, and A Lima
School of Electrical and Computer Engineering, National Technical University of Athens, Iroon Politechniou 9, Zografou Campus, 157 80 Athens, Greece. chmaria@central.ntua.gr

The bark extract of Pinus Maritima (PBE), a rich in phenolic acids, polyphenols and in particular flavonoids mixture, was examined for skin cancer preventive action that was evaluated in two different experimental animal tumor models induced by ultraviolet radiation (UVR) and combination of UVR with 7,12-dimethylbenz[a]anthracene. Significant decrease in the number of animals bearing tumors and the number of tumors per animal was observed in the PBE treated animals. In the same time significant increase in the viability of these animals was also observed. Furthermore, PBE delayed the appearance of tumors. These results provide strong evidence about the preventive anticancer activity of this extract on non-melanoma skin cancer and its protective effect not only from UVR, but also from more potent carcinogenic agents.

UI MeSH Term Description Entries
D008297 Male Males
D008543 Melanins Insoluble polymers of TYROSINE derivatives found in and causing darkness in skin (SKIN PIGMENTATION), hair, and feathers providing protection against SUNBURN induced by SUNLIGHT. CAROTENES contribute yellow and red coloration. Allomelanins,Melanin,Phaeomelanins
D008812 Mice, Hairless Mutant strains of mice that produce little or no hair. Hairless Mice,Mice, Inbred HRS,Mice, hr,Hairless Mouse,Mice, HRS,Mouse, HRS,Mouse, Inbred HRS,HRS Mice,HRS Mice, Inbred,HRS Mouse,HRS Mouse, Inbred,Inbred HRS Mice,Inbred HRS Mouse,Mouse, Hairless
D009381 Neoplasms, Radiation-Induced Tumors, cancer or other neoplasms produced by exposure to ionizing or non-ionizing radiation. Radiation-Induced Cancer,Cancer, Radiation-Induced,Radiation-Induced Neoplasms,Cancer, Radiation Induced,Cancers, Radiation-Induced,Neoplasm, Radiation-Induced,Neoplasms, Radiation Induced,Radiation Induced Cancer,Radiation Induced Neoplasms,Radiation-Induced Cancers,Radiation-Induced Neoplasm
D002273 Carcinogens Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D005260 Female Females
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D012878 Skin Neoplasms Tumors or cancer of the SKIN. Cancer of Skin,Skin Cancer,Cancer of the Skin,Neoplasms, Skin,Cancer, Skin,Cancers, Skin,Neoplasm, Skin,Skin Cancers,Skin Neoplasm
D013997 Time Factors Elements of limited time intervals, contributing to particular results or situations. Time Series,Factor, Time,Time Factor
D014466 Ultraviolet Rays That portion of the electromagnetic spectrum immediately below the visible range and extending into the x-ray frequencies. The longer wavelengths (near-UV or biotic or vital rays) are necessary for the endogenous synthesis of vitamin D and are also called antirachitic rays; the shorter, ionizing wavelengths (far-UV or abiotic or extravital rays) are viricidal, bactericidal, mutagenic, and carcinogenic and are used as disinfectants. Actinic Rays,Black Light, Ultraviolet,UV Light,UV Radiation,Ultra-Violet Rays,Ultraviolet Light,Ultraviolet Radiation,Actinic Ray,Light, UV,Light, Ultraviolet,Radiation, UV,Radiation, Ultraviolet,Ray, Actinic,Ray, Ultra-Violet,Ray, Ultraviolet,Ultra Violet Rays,Ultra-Violet Ray,Ultraviolet Black Light,Ultraviolet Black Lights,Ultraviolet Radiations,Ultraviolet Ray

Related Publications

Maria Kyriazi, and Dido Yova, and Michail Rallis, and A Lima
July 2009, Environmental toxicology and pharmacology,
Maria Kyriazi, and Dido Yova, and Michail Rallis, and A Lima
March 2012, Journal of environmental biology,
Maria Kyriazi, and Dido Yova, and Michail Rallis, and A Lima
October 1990, Photodermatology, photoimmunology & photomedicine,
Maria Kyriazi, and Dido Yova, and Michail Rallis, and A Lima
April 1991, Photodermatology, photoimmunology & photomedicine,
Maria Kyriazi, and Dido Yova, and Michail Rallis, and A Lima
December 2001, Fitoterapia,
Maria Kyriazi, and Dido Yova, and Michail Rallis, and A Lima
November 2011, European journal of pharmacology,
Maria Kyriazi, and Dido Yova, and Michail Rallis, and A Lima
May 1999, Phytotherapy research : PTR,
Maria Kyriazi, and Dido Yova, and Michail Rallis, and A Lima
January 2006, Asian Pacific journal of cancer prevention : APJCP,
Maria Kyriazi, and Dido Yova, and Michail Rallis, and A Lima
December 2007, Integrative cancer therapies,
Copied contents to your clipboard!