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tritiated thymidine is incorporated into DNA of spermatogonia type B as proved by autohistoradiography when injected in vivo three hours before the sacrifice. Maximum binding and specific activity (labelled thymidine expressed in DPM per mg DNA) are obtained in pubertal rats aged 42 days and weighting 150 g. Inhibin preparation extracted from rete testis fluid (RTF3) specifically inhibits tritiated thymidine into testicular DNA. Thus, no modification of incorporation into hepatic DNA is observed and the preparation loses its inhibitory effect when denatured by heating and trypsin digestion. Tritiated thymidine incorporation into testicular DNA is poor in normal adult rats and in pubertal hypophysectomized animals, RTF3 does not modify the thymidine incorporation in both conditions. The reasons for this lack of effect are discussed. An experimental condition of spermatogonial regeneration is obtained by testicular irradiation. Inhibin preparation inhibits the regenerative DNA synthesis.
R Bologne, and
A Demoulin, and
J Hustin, and
J Verstraelen-Proyard, and
P Gysen, and
P Franchimont
November 1960,
Nature,
R Bologne, and
A Demoulin, and
J Hustin, and
J Verstraelen-Proyard, and
P Gysen, and
P Franchimont
January 1963,
Biochimica et biophysica acta,
R Bologne, and
A Demoulin, and
J Hustin, and
J Verstraelen-Proyard, and
P Gysen, and
P Franchimont
January 1963,
Neoplasma,
R Bologne, and
A Demoulin, and
J Hustin, and
J Verstraelen-Proyard, and
P Gysen, and
P Franchimont
March 1970,
The Journal of biological chemistry,
R Bologne, and
A Demoulin, and
J Hustin, and
J Verstraelen-Proyard, and
P Gysen, and
P Franchimont
August 1958,
The Journal of biological chemistry,
R Bologne, and
A Demoulin, and
J Hustin, and
J Verstraelen-Proyard, and
P Gysen, and
P Franchimont
December 1965,
Naunyn-Schmiedebergs Archiv fur experimentelle Pathologie und Pharmakologie,
R Bologne, and
A Demoulin, and
J Hustin, and
J Verstraelen-Proyard, and
P Gysen, and
P Franchimont
February 1966,
Nature,
R Bologne, and
A Demoulin, and
J Hustin, and
J Verstraelen-Proyard, and
P Gysen, and
P Franchimont
December 1973,
Brain research,
R Bologne, and
A Demoulin, and
J Hustin, and
J Verstraelen-Proyard, and
P Gysen, and
P Franchimont
January 1990,
Digestion,
R Bologne, and
A Demoulin, and
J Hustin, and
J Verstraelen-Proyard, and
P Gysen, and
P Franchimont
January 1961,
Biochemical and biophysical research communications,
