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Vertebrate T cells express either an alpha beta or gamma delta T cell receptor (TCR). The developmental relatedness of the two cell types is unresolved. alpha beta + T cells respond to specific pathogens by collaborating with immunoglobulin-producing B cells in distinct lymphoid organs such as the spleen and Peyer's patches. The precise influence of alpha beta + T cells on B cell development is poorly understood. To investigate the developmental effects of alpha beta + T cells on B cells and gamma delta + T cells, mice homozygous for a disrupted TCR alpha gene were generated. The homozygotes showed elimination of alpha beta + T cells and the loss of thymic medullae. Despite this, gamma delta + T cells developed in normal numbers, and there was an increase in splenic B cells.
K L Philpott, and
J L Viney, and
G Kay, and
S Rastan, and
E M Gardiner, and
S Chae, and
A C Hayday, and
M J Owen
December 1994,
Proceedings of the National Academy of Sciences of the United States of America,
K L Philpott, and
J L Viney, and
G Kay, and
S Rastan, and
E M Gardiner, and
S Chae, and
A C Hayday, and
M J Owen
August 1995,
Immunology,
K L Philpott, and
J L Viney, and
G Kay, and
S Rastan, and
E M Gardiner, and
S Chae, and
A C Hayday, and
M J Owen
July 1996,
European journal of immunology,
K L Philpott, and
J L Viney, and
G Kay, and
S Rastan, and
E M Gardiner, and
S Chae, and
A C Hayday, and
M J Owen
September 1995,
European journal of immunology,
K L Philpott, and
J L Viney, and
G Kay, and
S Rastan, and
E M Gardiner, and
S Chae, and
A C Hayday, and
M J Owen
May 1999,
The Journal of experimental medicine,
K L Philpott, and
J L Viney, and
G Kay, and
S Rastan, and
E M Gardiner, and
S Chae, and
A C Hayday, and
M J Owen
January 1991,
Current topics in microbiology and immunology,
K L Philpott, and
J L Viney, and
G Kay, and
S Rastan, and
E M Gardiner, and
S Chae, and
A C Hayday, and
M J Owen
April 1990,
The Journal of experimental medicine,
K L Philpott, and
J L Viney, and
G Kay, and
S Rastan, and
E M Gardiner, and
S Chae, and
A C Hayday, and
M J Owen
June 1994,
Nature,
K L Philpott, and
J L Viney, and
G Kay, and
S Rastan, and
E M Gardiner, and
S Chae, and
A C Hayday, and
M J Owen
December 1995,
Immunity,
K L Philpott, and
J L Viney, and
G Kay, and
S Rastan, and
E M Gardiner, and
S Chae, and
A C Hayday, and
M J Owen
November 1996,
Immunity,
