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Cardiac output was determined by means of radioactive microspheres, 15 +/- 5 microns in diameter. Blood flow in the ascending aorta was measured by an electromagnetic flowmeter. In eight cats thirty-eight simultaneous measurements were made of cardiac output and aortic flow. The observations correlated well (r = 0.89), with a mean difference of 5.2%, probably corresponding to coronary blood flow. Continuous flow recordings showed no alterations in aortic flow during the injections of microspheres; arterial blood pressure and heart rate remained unchanged even after six injections, each consisting of about 2 x 10(5) spheres per kg body weight. Tests for shunting of microspheres were performed and revealed shunt fractions in the systemic circulation of about 8%, with no significant shunting through the lungs. The microsphere method for determining cardiac output is thought to be an accurate method, suitable for small and medium sized animals.
L Segadal, and
K Svanes
January 1979,
European surgical research. Europaische chirurgische Forschung. Recherches chirurgicales europeennes,
L Segadal, and
K Svanes
June 1986,
Clinical physiology (Oxford, England),
L Segadal, and
K Svanes
January 1974,
Investigative radiology,
L Segadal, and
K Svanes
February 1957,
Radiology,
L Segadal, and
K Svanes
January 1971,
Giornale italiano di cardiologia,
L Segadal, and
K Svanes
April 1963,
Archivio di fisiologia,
L Segadal, and
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April 2004,
Respiratory physiology & neurobiology,
L Segadal, and
K Svanes
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Zeitschrift fur Kreislaufforschung,
L Segadal, and
K Svanes
April 1989,
International journal of cardiology,
L Segadal, and
K Svanes
January 1979,
Computer programs in biomedicine,
