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Cytogenetic studies were performed in 74 untreated patients with acute nonlymphocytic leukemia (ANLL) between 1985 and 1988. Among 56 patients who were examined successfully at the time of diagnosis, 36 had abnormal karyotypes (64.2%). The distribution of chromosome abnormalities was uneven, according to the categories of the French-American-British (FAB) nomenclature. The highest frequency of chromosome abnormalities was observed in ANLL M4 with bone marrow (BM) eosinophilia (M4Eo). Numerical changes were observed in 11 cases; chromosome 8 was most frequently gained (11 patients), whereas chromosome 7 was most frequently lost (4 patients). Structural rearrangements were detected in 18 patients. Involvement of 16q22 was noted in 7 patients, 5q- was noted in 5, t(8;21) in 3, t(1;7) in 2, del(20) in 2, and involvement of 11q23 was noted in 2. The inversion of chromosome 16 was restricted to the M4Eo subtype. This study identified a novel abnormality [inv(2) (p11.2q11.2)] that had not been reported previously by other investigators.
F Solé, and
M R Caballín, and
M D Coll, and
S Woessner, and
C Besses, and
J Sans-Sabrafen, and
J Egozcue
April 1995,
Zhonghua yi xue za zhi = Chinese medical journal; Free China ed,
F Solé, and
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S Woessner, and
C Besses, and
J Sans-Sabrafen, and
J Egozcue
August 1988,
Cancer genetics and cytogenetics,
F Solé, and
M R Caballín, and
M D Coll, and
S Woessner, and
C Besses, and
J Sans-Sabrafen, and
J Egozcue
July 1991,
[Rinsho ketsueki] The Japanese journal of clinical hematology,
F Solé, and
M R Caballín, and
M D Coll, and
S Woessner, and
C Besses, and
J Sans-Sabrafen, and
J Egozcue
November 1978,
Virchows Archiv. B, Cell pathology,
F Solé, and
M R Caballín, and
M D Coll, and
S Woessner, and
C Besses, and
J Sans-Sabrafen, and
J Egozcue
January 1992,
Cancer genetics and cytogenetics,
F Solé, and
M R Caballín, and
M D Coll, and
S Woessner, and
C Besses, and
J Sans-Sabrafen, and
J Egozcue
March 1981,
Cancer genetics and cytogenetics,
F Solé, and
M R Caballín, and
M D Coll, and
S Woessner, and
C Besses, and
J Sans-Sabrafen, and
J Egozcue
February 1992,
Cancer genetics and cytogenetics,
F Solé, and
M R Caballín, and
M D Coll, and
S Woessner, and
C Besses, and
J Sans-Sabrafen, and
J Egozcue
January 1981,
The American journal of pediatric hematology/oncology,
F Solé, and
M R Caballín, and
M D Coll, and
S Woessner, and
C Besses, and
J Sans-Sabrafen, and
J Egozcue
March 1992,
Cancer genetics and cytogenetics,
F Solé, and
M R Caballín, and
M D Coll, and
S Woessner, and
C Besses, and
J Sans-Sabrafen, and
J Egozcue
August 2001,
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,
