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The pharmacokinetics of vinorelbine has been investigated by a new HPLC method in 8 cancer patients receiving 8 weekly doses (30 mg.m-2) administered by brief infusion (15 min). The plasma concentration-time curves showed a tri-exponential decay with a long terminal half-life (44.7 h) and a high volume of distribution (Vz = 75.61.kg-1). The concentrations after the 8th infusion were significantly lower than after the 1st infusion, but without significant modification of CL (1.28 l.h-1.kg-1) or AUC (0.80 mg.l-1.h). The pharmacokinetic parameters exhibited wide interindividual variations. The results are consistent with those of previous RIA studies, although the HPLC method appears to be more specific and more precise.
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G Lachatre, and
J Debord, and
B Eichler, and
F Bonnaud, and
G Nicot
September 1996,
Clinical pharmacokinetics,
P Marquet, and
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G Nicot
October 1994,
Seminars in oncology,
P Marquet, and
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Cancer chemotherapy and pharmacology,
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P Marquet, and
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December 1992,
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P Marquet, and
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January 1980,
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P Marquet, and
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G Nicot
January 2009,
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P Marquet, and
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B Eichler, and
F Bonnaud, and
G Nicot
January 1971,
Clinical pharmacology and therapeutics,
