-transparent.png){kind=logo}
The bioequivalence of two sustained-release preparations of quinidine bisulphate from Teva (Israel) and from Astra (Sweden) was assessed in an acute, single-dose randomized cross-over study in seven healthy subjects. There was no significant difference in time to peak, peak serum concentration, area under the concentration time curve from 0 to infinity, and the fraction absorbed between quinidine bisulphate 500 mg from Teva and from Astra. In addition, quinidine bisulphate 250 mg from Teva was compared with the short-acting quinidine sulphate 200 mg. The quinidine bisulphate from Teva had a significantly P less than 0.025) decreased peak serum concentration and an increased time to peak compared with the short-acting quinidine sulphate, although these two drugs are similar for the area under the curve from 0 to infinity. Our pharmaceutical records show that 85% of outpatients receiving quinidine are given the sustained-release quinidine bisulphate. However, only 36% of the outpatients prescribed sustained-release quinidine bisulphate are appropriately prescribed for twice-daily treatment. Thus the quinidine bisulphate from Teva is a sustained-release preparation with bioequivalence to the reference sustained-release preparation and can be administered twice daily.
M Garty, and
A Rachmel, and
D Ilfeld, and
Y Sinai, and
R Paz
August 1979,
European journal of clinical pharmacology,
M Garty, and
A Rachmel, and
D Ilfeld, and
Y Sinai, and
R Paz
January 1983,
Clinical therapeutics,
M Garty, and
A Rachmel, and
D Ilfeld, and
Y Sinai, and
R Paz
January 1980,
Acta medica Scandinavica,
M Garty, and
A Rachmel, and
D Ilfeld, and
Y Sinai, and
R Paz
April 1999,
The Journal of the Association of Physicians of India,
M Garty, and
A Rachmel, and
D Ilfeld, and
Y Sinai, and
R Paz
January 1996,
Arzneimittel-Forschung,
M Garty, and
A Rachmel, and
D Ilfeld, and
Y Sinai, and
R Paz
March 1991,
Arzneimittel-Forschung,
M Garty, and
A Rachmel, and
D Ilfeld, and
Y Sinai, and
R Paz
November 1994,
Arzneimittel-Forschung,
M Garty, and
A Rachmel, and
D Ilfeld, and
Y Sinai, and
R Paz
March 1998,
Arzneimittel-Forschung,
M Garty, and
A Rachmel, and
D Ilfeld, and
Y Sinai, and
R Paz
October 1992,
International journal of clinical pharmacology, therapy, and toxicology,
M Garty, and
A Rachmel, and
D Ilfeld, and
Y Sinai, and
R Paz
January 1984,
Clinical therapeutics,
