Responses to species-specific vocalizations in the auditory cortex of awake and anesthetized guinea pigs. 2005

Josef Syka, and Daniel Suta, and Jirí Popelár
Institute of Experimental Medicine, Academy of Sciences of the Czech Republic, Videnská 1083, 142 20 Prague, Czech Republic. syka@biomed.cas.cz

Species-specific vocalizations represent an important acoustical signal that must be decoded in the auditory system of the listener. We were interested in examining to what extent anesthesia may change the process of signal decoding in neurons of the auditory cortex in the guinea pig. With this aim, the multiple-unit activity, either spontaneous or acoustically evoked, was recorded in the auditory cortex of guinea pigs, at first in the awake state and then after the injection of anesthetics (33 mg/kg ketamine with 6.6 mg/kg xylazine). Acoustical stimuli, presented in free-field conditions, consisted of four typical guinea pig calls (purr, chutter, chirp and whistle), a time-reversed version of the whistle and a broad-band noise burst. The administration of anesthesia typically resulted in a decrease in the level of spontaneous activity and in changes in the strength of the neuronal response to acoustical stimuli. The effect of anesthesia was mostly, but not exclusively, suppressive. Diversity in the effects of anesthesia led in some recordings to an enhanced response to one call accompanied by a suppressed response to another call. The temporal pattern of the response to vocalizations was changed in some cases under anesthesia, which may indicate a change in the synaptic input of the recorded neurons. In summary, our results suggest that anesthesia must be considered as an important factor when investigating the processing of complex sounds such as species-specific vocalizations in the auditory cortex.

UI MeSH Term Description Entries
D008297 Male Males
D012044 Regression Analysis Procedures for finding the mathematical function which best describes the relationship between a dependent variable and one or more independent variables. In linear regression (see LINEAR MODELS) the relationship is constrained to be a straight line and LEAST-SQUARES ANALYSIS is used to determine the best fit. In logistic regression (see LOGISTIC MODELS) the dependent variable is qualitative rather than continuously variable and LIKELIHOOD FUNCTIONS are used to find the best relationship. In multiple regression, the dependent variable is considered to depend on more than a single independent variable. Regression Diagnostics,Statistical Regression,Analysis, Regression,Analyses, Regression,Diagnostics, Regression,Regression Analyses,Regression, Statistical,Regressions, Statistical,Statistical Regressions
D005072 Evoked Potentials, Auditory The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS. Auditory Evoked Potentials,Auditory Evoked Response,Auditory Evoked Potential,Auditory Evoked Responses,Evoked Potential, Auditory,Evoked Response, Auditory,Evoked Responses, Auditory,Potentials, Auditory Evoked
D006168 Guinea Pigs A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research. Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D000161 Acoustic Stimulation Use of sound to elicit a response in the nervous system. Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001303 Auditory Cortex The region of the cerebral cortex that receives the auditory radiation from the MEDIAL GENICULATE BODY. Brodmann Area 41,Brodmann Area 42,Brodmann's Area 41,Heschl Gyrus,Heschl's Gyrus,Auditory Area,Heschl's Convolutions,Heschl's Gyri,Primary Auditory Cortex,Temporal Auditory Area,Transverse Temporal Gyri,Area 41, Brodmann,Area 41, Brodmann's,Area 42, Brodmann,Area, Auditory,Area, Temporal Auditory,Auditory Areas,Auditory Cortex, Primary,Brodmanns Area 41,Cortex, Auditory,Cortex, Primary Auditory,Gyrus, Heschl,Gyrus, Heschl's,Gyrus, Transverse Temporal,Heschl Convolutions,Heschl Gyri,Heschls Convolutions,Heschls Gyri,Heschls Gyrus,Primary Auditory Cortices,Temporal Auditory Areas,Temporal Gyrus, Transverse,Transverse Temporal Gyrus
D001307 Auditory Perception The process whereby auditory stimuli are selected, organized, and interpreted by the organism. Auditory Processing,Perception, Auditory,Processing, Auditory
D013018 Sound Spectrography The graphic registration of the frequency and intensity of sounds, such as speech, infant crying, and animal vocalizations. Sonography, Speech,Sonography, Sound,Speech Sonography,Sonographies, Sound,Sound Sonographies,Sound Sonography,Spectrography, Sound
D013045 Species Specificity The restriction of a characteristic behavior, anatomical structure or physical system, such as immune response; metabolic response, or gene or gene variant to the members of one species. It refers to that property which differentiates one species from another but it is also used for phylogenetic levels higher or lower than the species. Species Specificities,Specificities, Species,Specificity, Species

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