BIOMAT Database Logo BIOMAT Database Logo

Effect of binge cocaine treatment on hindlimb vascular function. 2005

Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Department of Pharmacology, Tulane University Health Sciences Center, 1430 Tulane Avenue, New Orleans, LA 70112, USA.

Chronic cocaine abuse is known to cause endothelial dysfunction and atherosclerosis. The present study investigated the effect of binge cocaine treatment, a model for chronic cocaine abuse, on the blood flow responses to the adrenergic agonists norepinephrine, phenylephrine and isoproterenol, the endothelium-dependent vasodilator acetylcholine, and the endothelium independent vasodilator sodium nitroprusside (SNP) in the hindlimb vascular bed of male Sprague Dawley rats. Rats received either single binge or double binge treatment. Each binge treatment consisted of three doses of cocaine (30 mg kg(-1) i.p.) for 3 days. For double binge treatment, there was a 4 day recovery period between the binges. At the end of the treatment the rats were anesthetized and agonists were administered into the right hindlimb circulation through a catheter in the left iliac artery and blood flow responses were measured with a flow probe around the right iliac artery. Rats receiving double cocaine binges showed a significant decrease in the magnitude and duration of the blood flow response to norepinephrine and a decrease in the duration of the blood flow response to phenylephrine, isoproterenol and acetylcholine when compared with saline controls. The blood flow response to SNP was not changed. Total plasma nitrate-nitrite levels were significantly reduced and big endothelin levels were significantly increased in rats receiving double cocaine binges. This study demonstrates that binge cocaine treatment can alter endothelial function, while not changing smooth muscle function, and impairs the adrenergic pathway.

UI MeSH Term Description Entries
D008297 Male Males
D009599 Nitroprusside A powerful vasodilator used in emergencies to lower blood pressure or to improve cardiac function. It is also an indicator for free sulfhydryl groups in proteins. Nitroferricyanide,Sodium Nitroprusside,Cyanonitrosylferrate,Ketostix,Naniprus,Nipride,Nipruton,Nitriate,Nitropress,Nitroprussiat Fides,Nitroprusside, Disodium Salt,Nitroprusside, Disodium Salt, Dihydrate,Disodium Salt Nitroprusside,Nitroprusside, Sodium
D012039 Regional Blood Flow The flow of BLOOD through or around an organ or region of the body. Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D001920 Bradykinin A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter. Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg,Bradykinin Acetate, (9-D-Arg)-Isomer,Bradykinin Diacetate,Bradykinin Hydrochloride,Bradykinin Triacetate,Bradykinin, (1-D-Arg)-Isomer,Bradykinin, (2-D-Pro)-Isomer,Bradykinin, (2-D-Pro-3-D-Pro-7-D-Pro)-Isomer,Bradykinin, (2-D-Pro-7-D-Pro)-Isomer,Bradykinin, (3-D-Pro)-Isomer,Bradykinin, (3-D-Pro-7-D-Pro)-Isomer,Bradykinin, (5-D-Phe)-Isomer,Bradykinin, (5-D-Phe-8-D-Phe)-Isomer,Bradykinin, (6-D-Ser)-Isomer,Bradykinin, (7-D-Pro)-Isomer,Bradykinin, (8-D-Phe)-Isomer,Bradykinin, (9-D-Arg)-Isomer,Arg Pro Pro Gly Phe Ser Pro Phe Arg
D003042 Cocaine An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake. Cocaine HCl,Cocaine Hydrochloride,HCl, Cocaine,Hydrochloride, Cocaine
D004195 Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases. Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004730 Endothelium, Vascular Single pavement layer of cells which line the luminal surface of the entire vascular system and regulate the transport of macromolecules and blood components. Capillary Endothelium,Vascular Endothelium,Capillary Endotheliums,Endothelium, Capillary,Endotheliums, Capillary,Endotheliums, Vascular,Vascular Endotheliums
D006614 Hindlimb Either of two extremities of four-footed non-primate land animals. It usually consists of a FEMUR; TIBIA; and FIBULA; tarsals; METATARSALS; and TOES. (From Storer et al., General Zoology, 6th ed, p73) Hindlimbs
D000109 Acetylcholine A neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. 2-(Acetyloxy)-N,N,N-trimethylethanaminium,Acetilcolina Cusi,Acetylcholine Bromide,Acetylcholine Chloride,Acetylcholine Fluoride,Acetylcholine Hydroxide,Acetylcholine Iodide,Acetylcholine L-Tartrate,Acetylcholine Perchlorate,Acetylcholine Picrate,Acetylcholine Picrate (1:1),Acetylcholine Sulfate (1:1),Bromoacetylcholine,Chloroacetylcholine,Miochol,Acetylcholine L Tartrate,Bromide, Acetylcholine,Cusi, Acetilcolina,Fluoride, Acetylcholine,Hydroxide, Acetylcholine,Iodide, Acetylcholine,L-Tartrate, Acetylcholine,Perchlorate, Acetylcholine

Related Publications

Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Hindlimb unweighting affects rat vascular capacitance function.
September 2001, American journal of physiology. Heart and circulatory physiology,
Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Effect of ethacrynic acid on hindlimb vascular resistance of anephric dogs.
February 1971, The Journal of pharmacology and experimental therapeutics,
Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Effect of cocaine on left ventricular function.
January 1996, Circulation,
Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Effect of dihydro-ouabain on vascular tone on the perfused cannine hindlimb.
October 1976, The Journal of pharmacology and experimental therapeutics,
Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Reduced dopamine terminal function and insensitivity to cocaine following cocaine binge self-administration and deprivation.
August 2005, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Binge drinking impairs vascular function in young adults.
July 2013, Journal of the American College of Cardiology,
Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Binge cocaine self-administration by humans: smoked cocaine.
December 1997, Behavioural pharmacology,
Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Binge cocaine self-administration in humans: intravenous cocaine.
August 1997, Psychopharmacology,
Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Cocaine-like effect of ketamine on vascular adrenergic neurones.
August 1973, European journal of pharmacology,
Leena Pradhan, and Paul A Dabisch, and John T Liles, and S N Murthy, and Syed R Baber, and Scott A Simpson, and Krishna C Agrawal, and Philip J Kadowitz
Effect of chronic binge-like ethanol consumption on subsequent cocaine reinforcement in rhesus monkeys.
June 2021, Drug and alcohol dependence,
Copied contents to your clipboard!