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Serine proteinase inhibitors, in the seeds of several Leguminosae from the Pantanal region (West Brazil), were studied using bovine trypsin, Factor XIIa and human plasma kallikrein. The inhibitors were purified from Enterolobium contortisiliquum (Mr = 23,000), Torresea cearensis (Mr = 13,000), Bauhinia bauhinioides (Mr = 20,000), Bauhinia mollis (Mr = 20,000) and Bauhinia pentandra (Mr = 20,000). E. contortisiliquum inhibitor inactivates all three enzymes, whereas the T. cearensis inhibitor inactivates trypsin and Factor XIIa, but does not affect plasma kallikrein. B. bauhinioides and B. pentrandra inhibitors, on the other hand, inactivate trypsin and plasma kallikrein but only the B. pentandra inhibitor affects Factor XIIa, and B. mollis inhibitor causes trypsin inactivation only. Calculated Ki values were between 10(-7) and 10(-9) M. Chymotrypsin, like trypsin, is also inhibited, but with lower affinity. The trypsin inhibitors, isolated from E. contortisiliquum, B. pentandra, B. bauhinioides and B. mollis seem to be of the Kunitz type; the inhibitor purified from T. cearensis is of the Bowman-Birk type.
C A Sampaio, and
G Motta, and
M U Sampaio, and
M L Oliva, and
M S Araújo, and
R C Stella, and
A S Tanaka, and
I F Batista
September 2009,
Anais da Academia Brasileira de Ciencias,
C A Sampaio, and
G Motta, and
M U Sampaio, and
M L Oliva, and
M S Araújo, and
R C Stella, and
A S Tanaka, and
I F Batista
May 1996,
Immunopharmacology,
C A Sampaio, and
G Motta, and
M U Sampaio, and
M L Oliva, and
M S Araújo, and
R C Stella, and
A S Tanaka, and
I F Batista
June 1988,
Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic],
C A Sampaio, and
G Motta, and
M U Sampaio, and
M L Oliva, and
M S Araújo, and
R C Stella, and
A S Tanaka, and
I F Batista
February 1990,
The American journal of physiology,
C A Sampaio, and
G Motta, and
M U Sampaio, and
M L Oliva, and
M S Araújo, and
R C Stella, and
A S Tanaka, and
I F Batista
January 1981,
Terapevticheskii arkhiv,
C A Sampaio, and
G Motta, and
M U Sampaio, and
M L Oliva, and
M S Araújo, and
R C Stella, and
A S Tanaka, and
I F Batista
July 1990,
Infection and immunity,
C A Sampaio, and
G Motta, and
M U Sampaio, and
M L Oliva, and
M S Araújo, and
R C Stella, and
A S Tanaka, and
I F Batista
January 1990,
Journal of cardiovascular pharmacology,
C A Sampaio, and
G Motta, and
M U Sampaio, and
M L Oliva, and
M S Araújo, and
R C Stella, and
A S Tanaka, and
I F Batista
January 2011,
Contributions to nephrology,
C A Sampaio, and
G Motta, and
M U Sampaio, and
M L Oliva, and
M S Araújo, and
R C Stella, and
A S Tanaka, and
I F Batista
December 2012,
Acta physiologica (Oxford, England),
C A Sampaio, and
G Motta, and
M U Sampaio, and
M L Oliva, and
M S Araújo, and
R C Stella, and
A S Tanaka, and
I F Batista
April 1982,
Sheng li ke xue jin zhan [Progress in physiology],
