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Gas uptake studies were carried out to evaluate kinetic interactions between 1,3-butadiene and styrene in Sprague-Dawley rats. The animals were co-exposed by inhalation to a mixture of 1,3-butadiene between 20 and 6000 ppm (v/v) and styrene between 0 and 500 ppm. The data demonstrate that metabolism of 1,3-butadiene was partially inhibited by styrene. The inhibition was competitive at atmospheric concentrations of styrene up to 90 ppm. Higher concentrations of styrene resulted in a small additional inhibition only. The apparent Michaelis-Menten constant for 1,3-butadiene, related to the average concentration in the organism of the animals, was Kmapp = 1.17 +/- 0.37 (mumol/l of tissue) and the corresponding atmospheric concentration at steady state was 560 ppm. The inhibition constant of styrene was found to be Ki = 0.23 +/- 0.30 (mumol/l of tissue). The maximal metabolic rate for 1,3-butadiene was 230 +/- 10 (mu/kg/h).
R J Laib, and
M Tucholski, and
J G Filser, and
G A Csanády
June 1990,
Environmental health perspectives,
R J Laib, and
M Tucholski, and
J G Filser, and
G A Csanády
December 2021,
Regulatory toxicology and pharmacology : RTP,
R J Laib, and
M Tucholski, and
J G Filser, and
G A Csanády
May 1997,
Chemico-biological interactions,
R J Laib, and
M Tucholski, and
J G Filser, and
G A Csanády
January 1993,
IARC scientific publications,
R J Laib, and
M Tucholski, and
J G Filser, and
G A Csanády
October 1996,
Toxicology,
R J Laib, and
M Tucholski, and
J G Filser, and
G A Csanády
March 2006,
International journal of hygiene and environmental health,
R J Laib, and
M Tucholski, and
J G Filser, and
G A Csanády
September 1983,
Toxicology letters,
R J Laib, and
M Tucholski, and
J G Filser, and
G A Csanády
December 2011,
Toxicology letters,
R J Laib, and
M Tucholski, and
J G Filser, and
G A Csanády
November 1986,
Mutagenesis,
R J Laib, and
M Tucholski, and
J G Filser, and
G A Csanády
January 1990,
Drugs under experimental and clinical research,
