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In ten patients with metastasizing melanomas, discontinuous intratumoral treatment with recombinant interferon beta (rIFN-beta) was administered into 19 cutaneous or palpable subcutaneous metastases. Among the 16 metastases treated with 5 x 10(6) IU per injection, 8 showed partial or complete remission. No recurrence was observed during the 4-9-month follow-up period. There was no regression in 3 metastases treated with 3 x 10(6) IU rINF-beta per injection. No systemic antineoplastic effects were observed in any of the cases. The IFN-beta serum levels were measurably increased following intratumoral application. Local treatment led to a significant increase in (2'-5')oligoadenylate synthetase in the mononuclear blood cells and in the serum. Side-effects of the treatment were moderate; there was a temporary increase in transaminases, a decrease in thrombocytes and influenza-like symptoms. The results show that IFN-beta has a dose-dependent antitumour effect on malignant melanomas.
G Fierlbeck, and
B d'Hoedt, and
W Stroebel, and
H Stutte, and
O Bogenschütz, and
G Rassner
September 2006,
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG,
G Fierlbeck, and
B d'Hoedt, and
W Stroebel, and
H Stutte, and
O Bogenschütz, and
G Rassner
June 1992,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
G Fierlbeck, and
B d'Hoedt, and
W Stroebel, and
H Stutte, and
O Bogenschütz, and
G Rassner
May 1993,
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete,
G Fierlbeck, and
B d'Hoedt, and
W Stroebel, and
H Stutte, and
O Bogenschütz, and
G Rassner
March 1988,
Cancer,
G Fierlbeck, and
B d'Hoedt, and
W Stroebel, and
H Stutte, and
O Bogenschütz, and
G Rassner
September 2011,
Journal of surgical oncology,
G Fierlbeck, and
B d'Hoedt, and
W Stroebel, and
H Stutte, and
O Bogenschütz, and
G Rassner
October 1994,
Cancer immunology, immunotherapy : CII,
G Fierlbeck, and
B d'Hoedt, and
W Stroebel, and
H Stutte, and
O Bogenschütz, and
G Rassner
December 2003,
Melanoma research,
G Fierlbeck, and
B d'Hoedt, and
W Stroebel, and
H Stutte, and
O Bogenschütz, and
G Rassner
January 1990,
Dermatologica,
G Fierlbeck, and
B d'Hoedt, and
W Stroebel, and
H Stutte, and
O Bogenschütz, and
G Rassner
April 2015,
Surgical oncology clinics of North America,
G Fierlbeck, and
B d'Hoedt, and
W Stroebel, and
H Stutte, and
O Bogenschütz, and
G Rassner
October 1997,
International journal of STD & AIDS,
