-transparent.png){kind=logo}
Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses. 2006
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
Department of Medicinal Chemistry, GlaxoSmithKline Research and Development, Research Triangle Park, NC 27709, USA. scott.h.allen@gsk.com
A novel series of potent C-6 substituted pyrazolo[1,5-a]pyridine inhibitors of herpes simplex viruses has been identified. A synthetic methodology was developed involving functionalization of a C-6 trifluoromethyl pyrazolo[1,5-a]pyridine to allow facile access to a diverse set of analogues from common late stage intermediates. The expansion of the SAR of this series at the 6 position allows for modifications to developability parameters such as clogP, while maintaining potency comparable to acyclovir.
Related Publications
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
April 2003,
Organic letters,
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
May 2007,
Bioorganic & medicinal chemistry letters,
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
June 2021,
Organic letters,
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
February 2010,
Organic letters,
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
January 2017,
Beilstein journal of organic chemistry,
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
October 2013,
Bioorganic & medicinal chemistry letters,
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
October 2008,
Bioorganic & medicinal chemistry letters,
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
January 2017,
Chemical & pharmaceutical bulletin,
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
March 2015,
Organic & biomolecular chemistry,
Scott H Allen, and
Brian A Johns, and
Kristjan S Gudmundsson, and
George A Freeman, and
F Leslie Boyd, and
Connie H Sexton, and
Dean W Selleseth, and
Katrina L Creech, and
Kelly R Moniri
October 2023,
Organic letters,
