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Synthesis and biological evaluation of novel C (7) modified chrysin analogues as antibacterial agents. 2006
K Suresh Babu, and
T Hari Babu, and
P V Srinivas, and
K Hara Kishore, and
U S N Murthy, and
J Madhusudana Rao
Division of Organic Chemistry-I, Indian Institute of Chemical Technology, Tarnaka, Hyderabad 500 007, India.
The natural product, chrysin (5,7-dihydroxy flavone), obtained from Oroxylum indicum, exhibits numerous biological activities including anticancer, anti-inflammatory, and antiallergic activities. Three series of chrysin analogues were prepared, in which chrysin and heterocyclic moieties are separated by 3-carbon, 4-carbon, and 6-carbon spacers. All the derivatives were screened for antibacterial activity against a panel of susceptible and resistant Gram-positive and Gram-negative organisms. It was observed that most of the derivatives displayed significant activity as compared to their parent compound (chrysin).
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