BIOMAT Database Logo BIOMAT Database Logo

[Historical and pharmalogical study of Citrus hassaku.]. 2005

Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima

The original plant of Citrus hassaku Hort. Tanaka was found at the Jyoudo Temple in Inno-shima, Hiroshima Prefecture, Japan by Ekei Shounin in the Edo Era. Citrus hassaku has been called "jagada" when it was first discovered. Since this fruit was seasoned for eating around "hassaku" (August 1st of the lunar calendar), it was given the scientific name as "C. hassaku." Today, the fresh raw fruits of C. Hassaku are cultivated as a seasonal food, and the most famous producing district of C. hassaku fruit is Wakayama Prefecture, representing about 60% of the Japanese output. The immature fruits of C. hassaku and its three main flavanone glycosides (naringin, neohesperidin and narirutin) was found to shown inhibitory activities on a compound 48/80 induced histamine released from mast cells, and anti-allergic effects on dinitrofluorobenzen (DNFB)-induced triphasic skin reactions in mice. The contents of the three flavanone glycosides in the immature fruits were higher than those in mature fruits. The application of extracts from the immature fruits of C. hassaku to skin care for patients with atopitic dermatitis has resulted in improving effects for 76% of the patients. Similar efficacy was obtained for patients pollinosis.

UI MeSH Term Description Entries
D008407 Mast Cells Granulated cells that are found in almost all tissues, most abundantly in the skin and the gastrointestinal tract. Like the BASOPHILS, mast cells contain large amounts of HISTAMINE and HEPARIN. Unlike basophils, mast cells normally remain in the tissues and do not circulate in the blood. Mast cells, derived from the bone marrow stem cells, are regulated by the STEM CELL FACTOR. Basophils, Tissue,Basophil, Tissue,Cell, Mast,Cells, Mast,Mast Cell,Tissue Basophil,Tissue Basophils
D008517 Phytotherapy Use of plants or herbs to treat diseases or to alleviate pain. Herb Therapy,Herbal Therapy
D008813 Mice, Inbred ICR An inbred strain of mouse that is used as a general purpose research strain, for therapeutic drug testing, and for the genetic analysis of CARCINOGEN-induced COLON CANCER. Mice, Inbred ICRC,Mice, ICR,Mouse, ICR,Mouse, Inbred ICR,Mouse, Inbred ICRC,ICR Mice,ICR Mice, Inbred,ICR Mouse,ICR Mouse, Inbred,ICRC Mice, Inbred,ICRC Mouse, Inbred,Inbred ICR Mice,Inbred ICR Mouse,Inbred ICRC Mice,Inbred ICRC Mouse
D002957 Citrus A plant genus of the family RUTACEAE. They bear the familiar citrus fruits including oranges, grapefruit, lemons, and limes. There are many hybrids which makes the nomenclature confusing. Citron Tree,Fruit, Citrus,Lemon Tree,Orange Tree, Bitter,Orange Tree, Mandarin,Orange Tree, Seville,Orange Tree, Sour,Pomelo Tree,Pummelo Tree,Tangerine Tree,Citrus Fruit,Citrus aurantium,Citrus bergamia,Citrus grandis,Citrus hystrix,Citrus limon,Citrus maxima,Citrus medica,Citrus reticulata,Kaffir Lime,Bitter Orange Tree,Bitter Orange Trees,Citron Trees,Citrus aurantiums,Citrus bergamias,Citrus grandi,Citrus hystrices,Citrus medicas,Citrus reticulatas,Lemon Trees,Lime, Kaffir,Mandarin Orange Tree,Mandarin Orange Trees,Orange Trees, Bitter,Orange Trees, Mandarin,Orange Trees, Seville,Orange Trees, Sour,Pomelo Trees,Pummelo Trees,Seville Orange Tree,Seville Orange Trees,Sour Orange Tree,Sour Orange Trees,Tangerine Trees,Tree, Bitter Orange,Tree, Citron,Tree, Lemon,Tree, Mandarin Orange,Tree, Pomelo,Tree, Pummelo,Tree, Seville Orange,Tree, Sour Orange,Tree, Tangerine,Trees, Bitter Orange,Trees, Citron,Trees, Lemon,Trees, Mandarin Orange,Trees, Pomelo,Trees, Pummelo,Trees, Seville Orange,Trees, Sour Orange,Trees, Tangerine,aurantium, Citrus,bergamia, Citrus,hystrices, Citrus,maxima, Citrus,medicas, Citrus,reticulata, Citrus
D003876 Dermatitis, Atopic A chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. It is manifested by lichenification, excoriation, and crusting, mainly on the flexural surfaces of the elbow and knee. In infants it is known as infantile eczema. Eczema, Atopic,Eczema, Infantile,Neurodermatitis, Atopic,Neurodermatitis, Disseminated,Atopic Dermatitis,Atopic Eczema,Atopic Neurodermatitis,Disseminated Neurodermatitis,Infantile Eczema
D006636 Histamine Release The secretion of histamine from mast cell and basophil granules by exocytosis. This can be initiated by a number of factors, all of which involve binding of IgE, cross-linked by antigen, to the mast cell or basophil's Fc receptors. Once released, histamine binds to a number of different target cell receptors and exerts a wide variety of effects. Histamine Liberation,Histamine Liberations,Histamine Releases
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000383 Agriculture The science, art or practice of cultivating soil, producing crops, and raising livestock. Agronomy,Agricultural Development,Farming,Agronomies,Development, Agricultural
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D049672 History, 19th Century Time period from 1801 through 1900 of the common era. 19th Century History,19th Cent. History (Medicine),19th Cent. History of Medicine,19th Cent. Medicine,Historical Events, 19th Century,History of Medicine, 19th Cent.,History, Nineteenth Century,Medical History, 19th Cent.,Medicine, 19th Cent.,19th Cent. Histories (Medicine),19th Century Histories,Cent. Histories, 19th (Medicine),Cent. History, 19th (Medicine),Century Histories, 19th,Century Histories, Nineteenth,Century History, 19th,Century History, Nineteenth,Histories, 19th Cent. (Medicine),Histories, 19th Century,Histories, Nineteenth Century,History, 19th Cent. (Medicine),Nineteenth Century Histories,Nineteenth Century History

Related Publications

Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima
Inhibitory effects of Citrus hassaku extract and its flavanone glycosides on melanogenesis.
March 2009, Biological & pharmaceutical bulletin,
Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima
An Efficient Synthesis of (±)-Hasakol, a Bioactive Coumarin from Citrus hassaku.
January 1996, Bioscience, biotechnology, and biochemistry,
Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima
Isolation and characterization of wound-induced compounds from the leaves of Citrus hassaku.
August 2016, Journal of bioscience and bioengineering,
Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima
Effects of unripe Citrus hassaku fruits extract and its flavanone glycosides on blood fluidity.
January 2010, Biological & pharmaceutical bulletin,
Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima
Citrus hassaku Extract Powder Increases Mitochondrial Content and Oxidative Muscle Fibers by Upregulation of PGC-1α in Skeletal Muscle.
February 2021, Nutrients,
Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima
Antiallergic activity of unripe Citrus hassaku fruits extract and its flavanone glycosides on chemical substance-induced dermatitis in mice.
October 2009, Journal of natural medicines,
Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima
[Clinical and pharmalogical aspects of digitalis].
June 1952, Arztliche Wochenschrift,
Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima
[Rape drugs: pharmalogical and analytical aspects].
January 2004, Annales de biologie clinique,
Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima
The age parameter of pharmalogical activity.
September 1961, Experientia,
Minchinori Kubo, and Hideaki Matsuda, and Norimichi Tomohiro, and Shouichi Harima
Cancer-related neuropathic pain: pharmalogical options.
January 2012, British journal of nursing (Mark Allen Publishing),
Copied contents to your clipboard!