Biomaterial Database

[Excitatory effect of low dose of manganese on spontaneous discharges of dorsal root ganglion neurons]. 2005

Rui-Hua Yang, and Jing-Yuan Chen, and San-Jue Hu

Department of Occupational and Environmental Health, Fourth Military Medical University, Xi'an 710033, China.

OBJECTIVE To investigate the toxicity of low dose of manganese on peripheral nervous system. METHODS With methods of the perfusion of dorsal root ganglion (DRG) in vitro and single fiber recording of the spontaneous discharges, the effect of manganese chloride (MnCl2 1, 2, 5, 10, 50, 100 micromol/L) on neurons were observed. RESULTS MnCl2 enhanced spontaneous discharges of DRG neurons in dose-dependent manner, but failed to affect the discharges of silent fibers. Different patterns of effects were observed in study. 1 micromol/L MnCl2 persistent enhanced the spontaneous discharges. The frequency of discharges reversed after a transient excitatory effect when 5 micromol/L MnCl2 was applied. However, 50 micromol/L MnCl2 gradually decreased the frequency of discharges followed a transient excitatory effect. CONCLUSIONS These results suggest that low dose of manganese enhanced the spontaneous discharges of DRG neurons. This may partially explain the mechanism of paraesthesia in slight poison of manganese.

UI	MeSH Term	Description	Entries
D008297	Male		Males
D008345	Manganese	A trace element with atomic symbol Mn, atomic number 25, and atomic weight 54.94. It is concentrated in cell mitochondria, mostly in the pituitary gland, liver, pancreas, kidney, and bone, influences the synthesis of mucopolysaccharides, stimulates hepatic synthesis of cholesterol and fatty acids, and is a cofactor in many enzymes, including arginase and alkaline phosphatase in the liver. (From AMA Drug Evaluations Annual 1992, p2035)
D009431	Neural Conduction	The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.	Nerve Conduction,Conduction, Nerve,Conduction, Neural,Conductions, Nerve,Conductions, Neural,Nerve Conductions,Neural Conductions
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D002712	Chlorides	Inorganic compounds derived from hydrochloric acid that contain the Cl- ion.	Chloride,Chloride Ion Level,Ion Level, Chloride,Level, Chloride Ion
D004305	Dose-Response Relationship, Drug	The relationship between the dose of an administered drug and the response of the organism to the drug.	Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004594	Electrophysiology	The study of the generation and behavior of electrical charges in living organisms particularly the nervous system and the effects of electricity on living organisms.
D004785	Environmental Pollutants	Substances or energies, for example heat or light, which when introduced into the air, water, or land threaten life or health of individuals or ECOSYSTEMS.	Environmental Pollutant,Pollutant,Pollutants,Pollutants, Environmental,Pollutant, Environmental
D005260	Female		Females
D005727	Ganglia, Spinal	Sensory ganglia located on the dorsal spinal roots within the vertebral column. The spinal ganglion cells are pseudounipolar. The single primary branch bifurcates sending a peripheral process to carry sensory information from the periphery and a central branch which relays that information to the spinal cord or brain.	Dorsal Root Ganglia,Spinal Ganglia,Dorsal Root Ganglion,Ganglion, Spinal,Ganglia, Dorsal Root,Ganglion, Dorsal Root,Spinal Ganglion