Bioinformatic analysis of circadian gene oscillation in mouse aorta. 2005

R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
The Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.

BACKGROUND Circadian rhythmicity of many aspects of cardiovascular function-blood pressure, coagulation and contractile function-is well established, as is diurnal variation in important clinical events, such as myocardial infarction and stroke. Here, we undertake studies to globally assess circadian gene expression in murine aorta. RESULTS Aortae from mice were harvested at 4-hour intervals for 2 circadian cycles (48 hours). Gene expression was assessed by expression profiling and subjected to a gene ontology bioinformatics analysis. Three hundred thirty transcripts exhibited a circadian pattern of oscillation in mouse aorta, including those intrinsic to the function of the molecular clock. In addition, many genes relevant to protein folding, protein degradation, glucose and lipid metabolism, adipocyte maturation, vascular integrity, and the response to injury are also included in this subset of roughly 7000 genes screened for circadian oscillation. CONCLUSIONS Detection of functional cassettes of vascular genes that exhibit circadian regulation in the mouse will facilitate elucidation of the mechanisms by which the molecular clock may interact with environmental variables to modulate cardiovascular function and the response to therapeutic interventions.

UI MeSH Term Description Entries
D008297 Male Males
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009693 Nucleic Acid Hybridization Widely used technique which exploits the ability of complementary sequences in single-stranded DNAs or RNAs to pair with each other to form a double helix. Hybridization can take place between two complimentary DNA sequences, between a single-stranded DNA and a complementary RNA, or between two RNA sequences. The technique is used to detect and isolate specific sequences, measure homology, or define other characteristics of one or both strands. (Kendrew, Encyclopedia of Molecular Biology, 1994, p503) Genomic Hybridization,Acid Hybridization, Nucleic,Acid Hybridizations, Nucleic,Genomic Hybridizations,Hybridization, Genomic,Hybridization, Nucleic Acid,Hybridizations, Genomic,Hybridizations, Nucleic Acid,Nucleic Acid Hybridizations
D009991 Oscillometry The measurement of frequency or oscillation changes. Oscillometries
D002940 Circadian Rhythm The regular recurrence, in cycles of about 24 hours, of biological processes or activities, such as sensitivity to drugs or environmental and physiological stimuli. Diurnal Rhythm,Nyctohemeral Rhythm,Twenty-Four Hour Rhythm,Nycthemeral Rhythm,Circadian Rhythms,Diurnal Rhythms,Nycthemeral Rhythms,Nyctohemeral Rhythms,Rhythm, Circadian,Rhythm, Diurnal,Rhythm, Nycthemeral,Rhythm, Nyctohemeral,Rhythm, Twenty-Four Hour,Rhythms, Circadian,Rhythms, Diurnal,Rhythms, Nycthemeral,Rhythms, Nyctohemeral,Rhythms, Twenty-Four Hour,Twenty Four Hour Rhythm,Twenty-Four Hour Rhythms
D003624 Darkness The absence of light. Darknesses
D005786 Gene Expression Regulation Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control (induction or repression) of gene action at the level of transcription or translation. Gene Action Regulation,Regulation of Gene Expression,Expression Regulation, Gene,Regulation, Gene Action,Regulation, Gene Expression
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D001013 Aorta, Thoracic The portion of the descending aorta proceeding from the arch of the aorta and extending to the DIAPHRAGM, eventually connecting to the ABDOMINAL AORTA. Aorta, Ascending,Aorta, Descending,Aortic Arch,Aortic Root,Arch of the Aorta,Descending Aorta,Sinotubular Junction,Ascending Aorta,Thoracic Aorta,Aortic Roots,Arch, Aortic,Ascending Aortas,Junction, Sinotubular,Root, Aortic,Sinotubular Junctions
D014158 Transcription, Genetic The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION. Genetic Transcription

Related Publications

R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
November 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology,
R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
December 2008, Bioinformatics (Oxford, England),
R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
September 1999, Brain research. Molecular brain research,
R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
March 2007, Molecular immunology,
R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
March 2010, Arteriosclerosis, thrombosis, and vascular biology,
R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
March 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research,
R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
July 2009, Biological & pharmaceutical bulletin,
R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
March 2006, Molecular endocrinology (Baltimore, Md.),
R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
March 2020, Molecules and cells,
R Daniel Rudic, and Peter McNamara, and Dermot Reilly, and Tilo Grosser, and Anne-Marie Curtis, and Thomas S Price, and Satchidananda Panda, and John B Hogenesch, and Garret A FitzGerald
January 2004, Photosynthesis research,
Copied contents to your clipboard!