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Two open-label, randomized, 2-way crossover studies (1 single-dose and 1 steady-state) were conducted in healthy volunteers to compare the pharmacokinetics and pharmacodynamics of a novel extended-release ciprofloxacin (ciprofloxacin ER; 500 mg once daily) and immediate-release ciprofloxacin (ciprofloxacin IR; 250 mg twice daily). For both studies, mean ciprofloxacin maximum concentration (Cmax) values after once-daily ciprofloxacin ER were significantly greater than those after the first daily dose of ciprofloxacin IR (P < .0001) but were lower than those after the second daily dose of ciprofloxacin IR (P < .05). The relative bioavailability of ciprofloxacin ER compared to ciprofloxacin IR was 93.8% in the single-dose study and 97.7% in the steady-state study. Mean urinary ciprofloxacin concentrations and excretion rates after either treatment were substantially greater than the minimum inhibitory concentrations (MICs) for susceptible uropathogens in both studies. The area under the concentration-time curve (AUC)/MIC, Cmax/MIC, amount excreted (Ae)/MIC, and Ae24/MIC ratios with ciprofloxacin ER were similar to or slightly greater than with ciprofloxacin IR for all susceptible organisms.
Carla B Washington, and
S Y E Hou, and
Corinne Campanella, and
Nicki Hughes, and
Steven Brown, and
Bret Berner
November 1994,
Clinical pharmacology and therapeutics,
Carla B Washington, and
S Y E Hou, and
Corinne Campanella, and
Nicki Hughes, and
Steven Brown, and
Bret Berner
January 2003,
Arzneimittel-Forschung,
Carla B Washington, and
S Y E Hou, and
Corinne Campanella, and
Nicki Hughes, and
Steven Brown, and
Bret Berner
September 1993,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
Carla B Washington, and
S Y E Hou, and
Corinne Campanella, and
Nicki Hughes, and
Steven Brown, and
Bret Berner
September 1995,
Hua xi yi ke da xue xue bao = Journal of West China University of Medical Sciences = Huaxi yike daxue xuebao,
Carla B Washington, and
S Y E Hou, and
Corinne Campanella, and
Nicki Hughes, and
Steven Brown, and
Bret Berner
February 1983,
International journal of clinical pharmacology, therapy, and toxicology,
Carla B Washington, and
S Y E Hou, and
Corinne Campanella, and
Nicki Hughes, and
Steven Brown, and
Bret Berner
December 1999,
Arzneimittel-Forschung,
Carla B Washington, and
S Y E Hou, and
Corinne Campanella, and
Nicki Hughes, and
Steven Brown, and
Bret Berner
July 2014,
Epilepsia,
Carla B Washington, and
S Y E Hou, and
Corinne Campanella, and
Nicki Hughes, and
Steven Brown, and
Bret Berner
January 2000,
European journal of clinical pharmacology,
Carla B Washington, and
S Y E Hou, and
Corinne Campanella, and
Nicki Hughes, and
Steven Brown, and
Bret Berner
June 2008,
Naunyn-Schmiedeberg's archives of pharmacology,
Carla B Washington, and
S Y E Hou, and
Corinne Campanella, and
Nicki Hughes, and
Steven Brown, and
Bret Berner
January 2015,
Frontiers in pharmacology,
