BIOMAT Database Logo BIOMAT Database Logo

Stereoselective synthesis of conformationally rigid apio carbanucleosides as potential antiviral agents. 2005

Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.

Apio north-methanocarbocyclic nucleosides 1-3 with bicyclo[3. 1.0]hexane template were first synthesized. Introduction of hydroxymethyl substituent was efficiently and stereoselectively accomplished by aldol and retro-aldol reaction and fixed conformation was achieved from a modified Simmons-Smith cyclopropanation on a cyclopentane ring.

UI MeSH Term Description Entries
D008956 Models, Chemical Theoretical representations that simulate the behavior or activity of chemical processes or phenomena; includes the use of mathematical equations, computers, and other electronic equipment. Chemical Models,Chemical Model,Model, Chemical
D008967 Molecular Biology A discipline concerned with studying biological phenomena in terms of the chemical and physical interactions of molecules. Biochemical Genetics,Biology, Molecular,Genetics, Biochemical,Genetics, Molecular,Molecular Genetics,Biochemical Genetic,Genetic, Biochemical,Genetic, Molecular,Molecular Genetic
D008968 Molecular Conformation The characteristic three-dimensional shape of a molecule. Molecular Configuration,3D Molecular Structure,Configuration, Molecular,Molecular Structure, Three Dimensional,Three Dimensional Molecular Structure,3D Molecular Structures,Configurations, Molecular,Conformation, Molecular,Conformations, Molecular,Molecular Configurations,Molecular Conformations,Molecular Structure, 3D,Molecular Structures, 3D,Structure, 3D Molecular,Structures, 3D Molecular
D009705 Nucleosides Purine or pyrimidine bases attached to a ribose or deoxyribose. (From King & Stansfield, A Dictionary of Genetics, 4th ed) Nucleoside,Nucleoside Analog,Nucleoside Analogs,Analog, Nucleoside,Analogs, Nucleoside
D010420 Pentanes Five-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Isopentanes
D011741 Pyrimidine Nucleosides Pyrimidines with a RIBOSE attached that can be phosphorylated to PYRIMIDINE NUCLEOTIDES. Nucleosides, Pyrimidine
D002384 Catalysis The facilitation of a chemical reaction by material (catalyst) that is not consumed by the reaction. Catalyses
D002626 Chemistry, Pharmaceutical Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use. Medicinal Chemistry,Chemistry, Pharmaceutic,Pharmaceutic Chemistry,Pharmaceutical Chemistry,Chemistry, Medicinal
D000096 Acetone A colorless liquid used as a solvent and an antiseptic. It is one of the ketone bodies produced during ketoacidosis.
D000998 Antiviral Agents Agents used in the prophylaxis or therapy of VIRUS DISEASES. Some of the ways they may act include preventing viral replication by inhibiting viral DNA polymerase; binding to specific cell-surface receptors and inhibiting viral penetration or uncoating; inhibiting viral protein synthesis; or blocking late stages of virus assembly. Antiviral,Antiviral Agent,Antiviral Drug,Antivirals,Antiviral Drugs,Agent, Antiviral,Agents, Antiviral,Drug, Antiviral,Drugs, Antiviral

Related Publications

Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
Synthesis of novel 3'-deoxy-3'-C-hydroxymethyl nucleosides with conformationally rigid sugar moiety as potential antiviral agents.
January 2001, Nucleosides, nucleotides & nucleic acids,
Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
Stereoselective synthesis of novel thioiso dideoxy nucleosides with exocyclic methylene as potential antiviral agents.
January 2005, Nucleosides, nucleotides & nucleic acids,
Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
Synthesis of as-triazines as potential antiviral agents.
May 1978, Journal of pharmaceutical sciences,
Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
Conformationally locked bicyclo[4.3.0]nonane carbanucleosides: synthesis and bio-evaluation.
December 2014, Organic & biomolecular chemistry,
Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
Regio- and stereoselective synthesis of carbocyclic 2',3'-dideoxy-3'-fluoro nucleosides as potential antiviral agents.
February 1994, Chemical & pharmaceutical bulletin,
Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
Synthesis of carbocyclic nucleosides as potential antiviral agents.
January 2001, Nucleic acids research. Supplement (2001),
Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
Stereoselective Approach for the Synthesis of Diverse 1'-Modified Carbanucleosides.
November 2023, Organic letters,
Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
Stereoselective synthesis of fluoro-homoneplanocin A as a potential antiviral agent.
April 2012, Organic letters,
Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
Synthesis of some new formazans as potential antiviral agents.
December 1981, Archiv der Pharmazie,
Hyung Ryong Moon, and Kyung Ran Kim, and Bum Tae Kim, and Ki Jun Hwang, and Moon Woo Chun, and Lak Shin Jeong
Synthesis of neplanocin F analogues as potential antiviral agents.
December 2006, Bioorganic & medicinal chemistry,
Copied contents to your clipboard!