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The leukocyte migration inhibition test (LMIT) was performed in 8 cases of presumed drug-induced pneumonitis. The drugs involved were amiodarone in 3 cases, methotrexate in 2 cases, and fenofibrate, nadolol, and gold salt, each in one case. The agarose microdroplet technique for photoelectric readings of leukocyte migration inhibition was applied in the presence of a wide range of drug concentrations. LMIT was found to be positive in 6 of the 8 cases (75%). The presence of a positive LMIT indicates the elaboration of leukocyte migration inhibitory factor. These results suggest that cell-mediated immunity may play a role in the pathogenesis of drug-induced pneumonitis and that LMIT may be useful for the detection of causative drugs in patients with this condition.
K Suzuki, and
S G Rahman, and
G M Akoun
December 1995,
Arerugi = [Allergy],
K Suzuki, and
S G Rahman, and
G M Akoun
November 1988,
Chest,
K Suzuki, and
S G Rahman, and
G M Akoun
August 1975,
Sovetskaia meditsina,
K Suzuki, and
S G Rahman, and
G M Akoun
March 1997,
Nihon rinsho. Japanese journal of clinical medicine,
K Suzuki, and
S G Rahman, and
G M Akoun
July 2005,
Nihon rinsho. Japanese journal of clinical medicine,
K Suzuki, and
S G Rahman, and
G M Akoun
November 1999,
Nihon rinsho. Japanese journal of clinical medicine,
K Suzuki, and
S G Rahman, and
G M Akoun
August 1975,
Sovetskaia meditsina,
K Suzuki, and
S G Rahman, and
G M Akoun
June 1981,
Polski tygodnik lekarski (Warsaw, Poland : 1960),
K Suzuki, and
S G Rahman, and
G M Akoun
October 1977,
International journal of dermatology,
K Suzuki, and
S G Rahman, and
G M Akoun
April 1981,
Rinsho byori. The Japanese journal of clinical pathology,
