BIOMAT Database Logo BIOMAT Database Logo

Effects of positive end-expiratory pressure on the canine venous return curve. 1992

H E Fessler, and R G Brower, and R A Wise, and S Permutt
Department of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224.

To study the mechanism whereby positive end-expiratory pressure (PEEP) decreases venous return, we used a closed-chest canine venous bypass preparation to study the effects of 10 mm Hg PEEP on the systemic venous pressure-flow curves from the superior and inferior vena cava (SVC and IVC). These curves were characterized by three variables: the critical downstream pressure below which venous return was maximal (PCRIT), the conductance to venous return (GVR), and the effective upstream pressure driving venous return. PEEP reduced venous return by decreasing the maximal venous return even when the pressures at the outflow of the IVC and SVC were maintained below zero. PEEP increased PCRIT in the SVC and IVC (SVC: -0.31 +/- 0.53 to 3.21 +/- 0.84; IVC: -0.41 +/- 0.64 to 5.23 +/- 1.02 (SE) mm Hg; p less than 0.005). GVR in the SVC was reduced (52.5 +/- 26 to 37.8 +/- 5.3 (SE) ml/min/mm Hg; p less than 0.005), but changes in the IVC did not reach statistical significance. These changes were partially offset by increases in the upstream pressure driving venous return (SVC: 9.44 +/- 0.54 to 12.25 +/- 0.71; IVC: 9.42 +/- 0.69 to 12.51 +/- 1.02 (SE) mm Hg; p less than 0.01). Analysis of these findings suggests that PEEP may alter venous return through effects on the peripheral circulation, independent of its effects on the heart.

UI MeSH Term Description Entries
D008297 Male Males
D011175 Positive-Pressure Respiration A method of mechanical ventilation in which pressure is maintained to increase the volume of gas remaining in the lungs at the end of expiration, thus reducing the shunting of blood through the lungs and improving gas exchange. Positive End-Expiratory Pressure,Positive-Pressure Ventilation,End-Expiratory Pressure, Positive,End-Expiratory Pressures, Positive,Positive End Expiratory Pressure,Positive End-Expiratory Pressures,Positive Pressure Respiration,Positive Pressure Ventilation,Positive-Pressure Respirations,Positive-Pressure Ventilations,Pressure, Positive End-Expiratory,Pressures, Positive End-Expiratory,Respiration, Positive-Pressure,Respirations, Positive-Pressure,Ventilation, Positive-Pressure,Ventilations, Positive-Pressure
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002302 Cardiac Output The volume of BLOOD passing through the HEART per unit of time. It is usually expressed as liters (volume) per minute so as not to be confused with STROKE VOLUME (volume per beat). Cardiac Outputs,Output, Cardiac,Outputs, Cardiac
D004285 Dogs The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065) Canis familiaris,Dog
D006339 Heart Rate The number of times the HEART VENTRICLES contract per unit of time, usually per minute. Cardiac Rate,Chronotropism, Cardiac,Heart Rate Control,Heartbeat,Pulse Rate,Cardiac Chronotropy,Cardiac Chronotropism,Cardiac Rates,Chronotropy, Cardiac,Control, Heart Rate,Heart Rates,Heartbeats,Pulse Rates,Rate Control, Heart,Rate, Cardiac,Rate, Heart,Rate, Pulse
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia
D014684 Venae Cavae The inferior and superior venae cavae. Cavae, Venae
D014690 Venous Pressure The blood pressure in the VEINS. It is usually measured to assess the filling PRESSURE to the HEART VENTRICLE. Blood Pressure, Venous,Blood Pressures, Venous,Pressure, Venous,Pressure, Venous Blood,Pressures, Venous,Pressures, Venous Blood,Venous Blood Pressure,Venous Blood Pressures,Venous Pressures

Related Publications

H E Fessler, and R G Brower, and R A Wise, and S Permutt
Comparison of the effects of positive end-expiratory pressure and jugular venous compression on canine cerebral venous pressure.
August 1984, Anesthesiology,
H E Fessler, and R G Brower, and R A Wise, and S Permutt
Setting positive end-expiratory pressure: using the pressure-volume curve.
February 2024, Current opinion in critical care,
H E Fessler, and R G Brower, and R A Wise, and S Permutt
[Effects of mechanical ventilation and positive end-expiratory on central venous pressure].
July 2011, Zhonghua yi xue za zhi,
H E Fessler, and R G Brower, and R A Wise, and S Permutt
[Effect of positive end-expiratory pressure on the pressure gradient of venous return in hypovolemic patients under mechanical ventilation].
October 2009, Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue,
H E Fessler, and R G Brower, and R A Wise, and S Permutt
Central venous pressure monitoring with positive end expiratory pressure.
May 1975, Journal of the Royal College of Surgeons of Edinburgh,
H E Fessler, and R G Brower, and R A Wise, and S Permutt
Effect of positive end-expiratory pressure on canine ventricular function curves.
December 1981, Journal of applied physiology: respiratory, environmental and exercise physiology,
H E Fessler, and R G Brower, and R A Wise, and S Permutt
[Hemodynamic effects of positive end-expiratory pressure].
June 2017, Giornale italiano di cardiologia (2006),
H E Fessler, and R G Brower, and R A Wise, and S Permutt
Hemodynamic effects of positive end-expiratory pressure.
February 2024, Current opinion in critical care,
H E Fessler, and R G Brower, and R A Wise, and S Permutt
Cardiorespiratory effects of positive end-expiratory pressure.
July 1994, Chest,
H E Fessler, and R G Brower, and R A Wise, and S Permutt
Effects of positive end-expiratory pressure ventilation on cerebral venous pressure with head elevation in dogs.
February 2000, Journal of applied physiology (Bethesda, Md. : 1985),
Copied contents to your clipboard!