Biomaterial Database

Regeneration and repair of peripheral nerves. 2005

Elizabeth O Johnson, and Aristides B Zoubos, and Panayotis N Soucacos

Department of Anatomy, Histology and Embryology, University of Ioannina, School of Medicine, 45110 Ioannina, Greece. ejohnson@cc.uoi.gr

Posttraumatic nerve repair continues to be a major challenge in restorative medicine and microsurgery. Although progress has been made in surgical techniques over the last 30 years, functional recovery after a severe lesion of a major nerve trunk is often incomplete and often unsatisfactory. Functional recovery after surgical repair of mixed nerves is even more disappointing. Functional recovery after peripheral nerve lesion is dependent upon accurate regeneration of axons to their original target tissues. Thus, in order to enhance regeneration, a better understanding of the cellular and molecular biology of selective nerve regeneration is required. Schwann cells and their endoneurial extracellular matrix play pivotal roles in the selective promotion of motor and sensory axon regeneration. Knowledge of these mechanisms allows for the better development of biocompatible nerve grafting material.

UI	MeSH Term	Description	Entries
D009416	Nerve Regeneration	Renewal or physiological repair of damaged nerve tissue.	Nerve Tissue Regeneration,Nervous Tissue Regeneration,Neural Tissue Regeneration,Nerve Tissue Regenerations,Nervous Tissue Regenerations,Neural Tissue Regenerations,Regeneration, Nerve,Regeneration, Nerve Tissue,Regeneration, Nervous Tissue,Regeneration, Neural Tissue,Tissue Regeneration, Nerve,Tissue Regeneration, Nervous,Tissue Regeneration, Neural
D009431	Neural Conduction	The propagation of the NERVE IMPULSE along the nerve away from the site of an excitation stimulus.	Nerve Conduction,Conduction, Nerve,Conduction, Neural,Conductions, Nerve,Conductions, Neural,Nerve Conductions,Neural Conductions
D009474	Neurons	The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM.	Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D010525	Peripheral Nerves	The nerves outside of the brain and spinal cord, including the autonomic, cranial, and spinal nerves. Peripheral nerves contain non-neuronal cells and connective tissue as well as axons. The connective tissue layers include, from the outside to the inside, the epineurium, the perineurium, and the endoneurium.	Endoneurium,Epineurium,Perineurium,Endoneuriums,Epineuriums,Nerve, Peripheral,Nerves, Peripheral,Perineuriums,Peripheral Nerve
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D059348	Peripheral Nerve Injuries	Injuries to the PERIPHERAL NERVES.	Peripheral Nerve Injury,Nerve Injuries, Peripheral,Nerve Injury, Peripheral
D020127	Recovery of Function	A partial or complete return to the normal or proper physiologic activity of an organ or part following disease or trauma.	Function Recoveries,Function Recovery
D023822	Tissue Engineering	Generating tissue in vitro for clinical applications, such as replacing wounded tissues or impaired organs. The use of TISSUE SCAFFOLDING enables the generation of complex multi-layered tissues and tissue structures.	Engineering, Tissue