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A double-blind study of the efficacy of adenine arabinoside in the treatment of patients with variola major was conducted. Adenine arabinoside (20 mg/kg of body weight) was given to patients intravenously every 24 hr for seven days in a 8-hr infusion. Five of the nine patients receiving adinine arabinoside died, and four of 11 patients receiving placebo died. Mortality was related to the severity of illness for both groups of patients. No difference was found between the drug and control groups in number of febrile days after initiation of therapy or in the period during which it was possible to isolate virus from skin lisions, throat swabs, and sources of clotted blood. Formation of scabs on skin lesions was complete 8.3 days after the initiation of therapy for the drug group and after 11.3 days for the control group. The findings suggest that adenine arabinoside is not effective in the chemotherapy of smallpox.
J P Koplan, and
K A Monsur, and
S O Foster, and
F Huq, and
M M Rahaman, and
S Huq, and
R A Buchanan, and
N A Ward
January 1975,
The Journal of infectious diseases,
J P Koplan, and
K A Monsur, and
S O Foster, and
F Huq, and
M M Rahaman, and
S Huq, and
R A Buchanan, and
N A Ward
April 1985,
Archives of disease in childhood,
J P Koplan, and
K A Monsur, and
S O Foster, and
F Huq, and
M M Rahaman, and
S Huq, and
R A Buchanan, and
N A Ward
April 1979,
Lancet (London, England),
J P Koplan, and
K A Monsur, and
S O Foster, and
F Huq, and
M M Rahaman, and
S Huq, and
R A Buchanan, and
N A Ward
February 1978,
The Medical journal of Australia,
J P Koplan, and
K A Monsur, and
S O Foster, and
F Huq, and
M M Rahaman, and
S Huq, and
R A Buchanan, and
N A Ward
March 1975,
The Journal of infectious diseases,
J P Koplan, and
K A Monsur, and
S O Foster, and
F Huq, and
M M Rahaman, and
S Huq, and
R A Buchanan, and
N A Ward
January 1986,
Journal of hepatology,
J P Koplan, and
K A Monsur, and
S O Foster, and
F Huq, and
M M Rahaman, and
S Huq, and
R A Buchanan, and
N A Ward
April 1977,
The Journal of infectious diseases,
J P Koplan, and
K A Monsur, and
S O Foster, and
F Huq, and
M M Rahaman, and
S Huq, and
R A Buchanan, and
N A Ward
October 1978,
Medizinische Klinik,
J P Koplan, and
K A Monsur, and
S O Foster, and
F Huq, and
M M Rahaman, and
S Huq, and
R A Buchanan, and
N A Ward
June 1979,
The British journal of ophthalmology,
J P Koplan, and
K A Monsur, and
S O Foster, and
F Huq, and
M M Rahaman, and
S Huq, and
R A Buchanan, and
N A Ward
November 1977,
Antimicrobial agents and chemotherapy,
