-transparent.png){kind=logo}
An assay for the determination of 4-aminopyridine in serum has been developed using 3,4-diaminopyridine as internal standard and reversed-phase high-performance liquid chromatography with detection at 244 nm. A mobile phase of acetonitrile-methanol-ethanol-1% ammonium carbonate (75:10:10:5) provided excellent separation of both compounds. Samples were extracted on solid-phase columns. The linearity, precision, recovery and the limit of detection were all sufficient for the routine use of this assay in clinical studies of patients treated with 4-aminopyridine.
Related Publications
A van der Horst, and
P N de Goede, and
H A van Diemen, and
C H Polman, and
H J Martens
December 1992,
Journal of chromatography,
A van der Horst, and
P N de Goede, and
H A van Diemen, and
C H Polman, and
H J Martens
August 1992,
Therapeutic drug monitoring,
A van der Horst, and
P N de Goede, and
H A van Diemen, and
C H Polman, and
H J Martens
May 1997,
Journal of pharmaceutical and biomedical analysis,
A van der Horst, and
P N de Goede, and
H A van Diemen, and
C H Polman, and
H J Martens
July 1995,
Journal of chromatography. B, Biomedical applications,
A van der Horst, and
P N de Goede, and
H A van Diemen, and
C H Polman, and
H J Martens
August 2001,
Biological & pharmaceutical bulletin,
A van der Horst, and
P N de Goede, and
H A van Diemen, and
C H Polman, and
H J Martens
May 2009,
Se pu = Chinese journal of chromatography,
A van der Horst, and
P N de Goede, and
H A van Diemen, and
C H Polman, and
H J Martens
May 1991,
Journal of chromatography,
A van der Horst, and
P N de Goede, and
H A van Diemen, and
C H Polman, and
H J Martens
June 2007,
Shokuhin eiseigaku zasshi. Journal of the Food Hygienic Society of Japan,
A van der Horst, and
P N de Goede, and
H A van Diemen, and
C H Polman, and
H J Martens
January 1997,
Alcohol (Fayetteville, N.Y.),
A van der Horst, and
P N de Goede, and
H A van Diemen, and
C H Polman, and
H J Martens
November 2001,
Se pu = Chinese journal of chromatography,
