BIOMAT Database Logo BIOMAT Database Logo

Changes in plasma amino acids after electroconvulsive therapy of depressed patients. 2005

Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
Department of Neurology, University of Tampere, and Department of Neurology, Tampere University Hospital, Tampere, Finland. johanna.palmio@uta.fi

There are indications that mood disorders may be related to perturbations in the amino acid transmitters. The amino acids may thus be targets of treatment of depression. The purpose of this pilot study was to measure the acute effects of a single administration of electroconvulsive therapy (ECT) on the plasma levels of amino acids in depressed patients. ECT was administered to 10 patients with major depressive disorder. Altogether 23 plasma amino acids were analyzed before and at 2, 6, 24 and 48 h after ECT. The levels of glutamate and aspartate increased at 6 h after ECT compared with the baseline. Also the levels of total tryptophan increased 2-24 h after ECT. There were also elevations in other amino acids at 6 and 24 h. The levels of gamma-aminobutyric acid (GABA) decreased at 2 h. In this study the acute effects of single ECT were associated with changes in the levels of glutamate, aspartate, GABA, tryptophan and some other amino acids. The preliminary data suggest that the therapeutic effects of ECT in depression may be due to mechanisms involving these amino acid transmitters.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D003865 Depressive Disorder, Major Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5) Depression, Involutional,Major Depressive Disorder,Melancholia, Involutional,Paraphrenia, Involutional,Psychosis, Involutional,Depressive Disorders, Major,Involutional Depression,Involutional Melancholia,Involutional Paraphrenia,Involutional Paraphrenias,Involutional Psychoses,Involutional Psychosis,Major Depressive Disorders,Paraphrenias, Involutional,Psychoses, Involutional
D004565 Electroconvulsive Therapy Electrically induced CONVULSIONS primarily used in the treatment of severe AFFECTIVE DISORDERS and SCHIZOPHRENIA. Convulsive Therapy, Electric,ECT (Psychotherapy),Electroshock Therapy,Shock Therapy, Electric,Convulsive Therapies, Electric,Electric Convulsive Therapies,Electric Convulsive Therapy,Electric Shock Therapies,Electric Shock Therapy,Electroconvulsive Therapies,Electroshock Therapies,Shock Therapies, Electric,Therapies, Electric Convulsive,Therapies, Electric Shock,Therapies, Electroconvulsive,Therapies, Electroshock,Therapy, Electric Convulsive,Therapy, Electric Shock,Therapy, Electroconvulsive,Therapy, Electroshock
D004569 Electroencephalography Recording of electric currents developed in the brain by means of electrodes applied to the scalp, to the surface of the brain, or placed within the substance of the brain. EEG,Electroencephalogram,Electroencephalograms
D004576 Electromyography Recording of the changes in electric potential of muscle by means of surface or needle electrodes. Electromyogram,Surface Electromyography,Electromyograms,Electromyographies,Electromyographies, Surface,Electromyography, Surface,Surface Electromyographies
D005260 Female Females
D005680 gamma-Aminobutyric Acid The most common inhibitory neurotransmitter in the central nervous system. 4-Aminobutyric Acid,GABA,4-Aminobutanoic Acid,Aminalon,Aminalone,Gammalon,Lithium GABA,gamma-Aminobutyric Acid, Calcium Salt (2:1),gamma-Aminobutyric Acid, Hydrochloride,gamma-Aminobutyric Acid, Monolithium Salt,gamma-Aminobutyric Acid, Monosodium Salt,gamma-Aminobutyric Acid, Zinc Salt (2:1),4 Aminobutanoic Acid,4 Aminobutyric Acid,Acid, Hydrochloride gamma-Aminobutyric,GABA, Lithium,Hydrochloride gamma-Aminobutyric Acid,gamma Aminobutyric Acid,gamma Aminobutyric Acid, Hydrochloride,gamma Aminobutyric Acid, Monolithium Salt,gamma Aminobutyric Acid, Monosodium Salt
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults

Related Publications

Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
Changes in heart rate variability of depressed patients after electroconvulsive therapy.
January 2012, Cardiovascular psychiatry and neurology,
Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
Structural-functional brain changes in depressed patients during and after electroconvulsive therapy.
February 2018, Acta neuropsychiatrica,
Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
[Determinants of relapse after electroconvulsive therapy in depressed patients].
November 2018, Fortschritte der Neurologie-Psychiatrie,
Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
Structural Changes in Depressed Patients Directly After Treatment With Electroconvulsive Therapy and 3 Months Later.
December 2023, The journal of ECT,
Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
Electroconvulsive therapy changes temporal dynamics of intrinsic brain activity in depressed patients.
October 2022, Psychiatry research,
Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
Changes in platelet 3H-imipramine binding in depressed patients receiving electroconvulsive therapy.
August 1988, Biological psychiatry,
Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
Tryptophan metabolite concentrations in depressed patients before and after electroconvulsive therapy.
January 2020, Brain, behavior, and immunity,
Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
Psychosis after electroconvulsive therapy in a depressed patient.
July 2019, The Australian and New Zealand journal of psychiatry,
Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
Calcium and electroconvulsive therapy of depressed patients.
August 1979, Biological psychiatry,
Johanna Palmio, and Martti Huuhka, and Pirjo Saransaari, and Simo S Oja, and Jukka Peltola, and Esa Leinonen, and Jaana Suhonen, and Tapani Keränen
Plasma amyloid-β levels in drug-resistant bipolar depressed patients receiving electroconvulsive therapy.
January 2013, Neuropsychobiology,
Copied contents to your clipboard!