Expression of human telomerase reverse transcriptase in thyroid follicular neoplasms: an immunohistochemical study. 2005

Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
Department of Pathology, Kaohsiung Medical University Hospital, Kaohsiung City, Taiwan.

Differential diagnosis of follicular adenoma (FA) and follicular carcinoma (FC) of the thyroid can be difficult in the routine practice of surgical pathology because the diagnosis of FC is strictly defined and determined by the presence of capsular and/or vascular invasion by the tumor. These features may be equivocal in the histologic sections. On the other hand, telomerase is expressed in many human cancers and is thought to contribute to their immortality. Human telomerase reverse transcriptase (hTERT) is the major determinant of human telomerase activity, and its expression is suggestive of capacity for unlimited replication. This case-control study examined the expression of hTERT using immunohistochemistry in 36 thyroid FC and 36 FA from patients who were matched by age and sex. The aim was to investigate the value of immunohistochemical staining for hTERT in the differential diagnosis of follicular neoplasms. The results revealed 23 cases of FC and 14 cases of FA that showed high expression of hTERT, with moderate to strong immunoreactivity. The remaining cases showed weak or negative staining. The difference between FA and FC was statistically significant (p < 0.05). In conclusion, immunohistochemical staining for hTERT can be considered an ancillary marker for differential diagnosis of FA and FC.

UI MeSH Term Description Entries
D007150 Immunohistochemistry Histochemical localization of immunoreactive substances using labeled antibodies as reagents. Immunocytochemistry,Immunogold Techniques,Immunogold-Silver Techniques,Immunohistocytochemistry,Immunolabeling Techniques,Immunogold Technics,Immunogold-Silver Technics,Immunolabeling Technics,Immunogold Silver Technics,Immunogold Silver Techniques,Immunogold Technic,Immunogold Technique,Immunogold-Silver Technic,Immunogold-Silver Technique,Immunolabeling Technic,Immunolabeling Technique,Technic, Immunogold,Technic, Immunogold-Silver,Technic, Immunolabeling,Technics, Immunogold,Technics, Immunogold-Silver,Technics, Immunolabeling,Technique, Immunogold,Technique, Immunogold-Silver,Technique, Immunolabeling,Techniques, Immunogold,Techniques, Immunogold-Silver,Techniques, Immunolabeling
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D011379 Prognosis A prediction of the probable outcome of a disease based on a individual's condition and the usual course of the disease as seen in similar situations. Prognostic Factor,Prognostic Factors,Factor, Prognostic,Factors, Prognostic,Prognoses
D003937 Diagnosis, Differential Determination of which one of two or more diseases or conditions a patient is suffering from by systematically comparing and contrasting results of diagnostic measures. Diagnoses, Differential,Differential Diagnoses,Differential Diagnosis
D004268 DNA-Binding Proteins Proteins which bind to DNA. The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. DNA Helix Destabilizing Proteins,DNA-Binding Protein,Single-Stranded DNA Binding Proteins,DNA Binding Protein,DNA Single-Stranded Binding Protein,SS DNA BP,Single-Stranded DNA-Binding Protein,Binding Protein, DNA,DNA Binding Proteins,DNA Single Stranded Binding Protein,DNA-Binding Protein, Single-Stranded,Protein, DNA-Binding,Single Stranded DNA Binding Protein,Single Stranded DNA Binding Proteins
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000236 Adenoma A benign epithelial tumor with a glandular organization. Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths

Related Publications

Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
January 2018, Journal of B.U.ON. : official journal of the Balkan Union of Oncology,
Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
June 1999, Clinical cancer research : an official journal of the American Association for Cancer Research,
Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
January 2005, Anticancer research,
Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
March 2009, Journal of the Medical Association of Thailand = Chotmaihet thangphaet,
Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
December 1999, Surgery,
Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
March 2003, Cancer letters,
Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
October 2008, Thyroid : official journal of the American Thyroid Association,
Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
January 2019, Journal of oral and maxillofacial pathology : JOMFP,
Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
July 2002, American journal of respiratory and critical care medicine,
Sheng-Lan Wang, and Wan-Tzu Chen, and Ming-Tsang Wu, and Hon-Man Chan, and Sheau-Fang Yang, and Chee-Yin Chai
January 2016, Journal of oral and maxillofacial pathology : JOMFP,
Copied contents to your clipboard!