-transparent.png){kind=logo}
Osteocalcin(OC) is a specific serum parameter of bone formation. Since bone metabolism disturbances, including osteoporosis, are seen in paraplegia, the serum levels of OC, midregional parathyroid hormone(mPTH), intact para-thyroid hormone (iPTH) and calcitonin (CT) serum levels were determined in 13 patients with paraplegia or tetraplegia and 15 control subjects by radioimmunoassay in a cross sectional study. In addition, the urinary hydroxyproline/creatine and the urinary calcium/creatinine ratio was determined. Serum OC levels were significantly increased in the patients with spinal cord injury (p less than 0.02), whereas serum levels of mPTH, iPTH and CT were not statistically different. The urinary hydroxyproline/creatinine ratio was significantly higher in the patients than in the controls (p less than 0.02), and the urinary calcium/creatinine ratio also tended to be higher in the patients. In a follow up study over 6 months after spinal cord injury, serum OC, serum iPTH, urinary hydroxyproline/creatinine ratio and the calcium/creatinine ratio were determined in 6 patients at monthly intervals. Hyperhydroxyprolinuria preceded the gradual increase of serum OC from normal to clearly elevated levels. Our data suggest that increased bone resorption in paraplegia is linked to an enhanced osteoblastic activity.
P Pietschmann, and
P Pils, and
W Woloszczuk, and
R Maerk, and
D Lessan, and
J Stipicic
January 1991,
The American journal of gastroenterology,
P Pietschmann, and
P Pils, and
W Woloszczuk, and
R Maerk, and
D Lessan, and
J Stipicic
April 1990,
Experimental and clinical endocrinology,
P Pietschmann, and
P Pils, and
W Woloszczuk, and
R Maerk, and
D Lessan, and
J Stipicic
January 1988,
Endocrinologie,
P Pietschmann, and
P Pils, and
W Woloszczuk, and
R Maerk, and
D Lessan, and
J Stipicic
February 1990,
Bone and mineral,
P Pietschmann, and
P Pils, and
W Woloszczuk, and
R Maerk, and
D Lessan, and
J Stipicic
January 1991,
Acta medica Austriaca,
P Pietschmann, and
P Pils, and
W Woloszczuk, and
R Maerk, and
D Lessan, and
J Stipicic
January 1989,
Journal of cancer research and clinical oncology,
P Pietschmann, and
P Pils, and
W Woloszczuk, and
R Maerk, and
D Lessan, and
J Stipicic
August 1986,
British journal of rheumatology,
P Pietschmann, and
P Pils, and
W Woloszczuk, and
R Maerk, and
D Lessan, and
J Stipicic
May 1988,
The Journal of clinical endocrinology and metabolism,
P Pietschmann, and
P Pils, and
W Woloszczuk, and
R Maerk, and
D Lessan, and
J Stipicic
March 1989,
Klinische Wochenschrift,
P Pietschmann, and
P Pils, and
W Woloszczuk, and
R Maerk, and
D Lessan, and
J Stipicic
June 2002,
Annals of the New York Academy of Sciences,
