Biomaterial Database

[Extracellular resistance of Yersinia pestis to phagocytosis]. 2005

V A Fedorova, and A B Golova

The authors were the first to perform stimulation of parasitizing condition of plague bacilli in mammalian bloodstream by addition of adequate quantity of glucose and calcium ions into the routine bacteriological medium, as well as growing the plague agent in RPMI-1640, isotonic to the serum of man and mammals susceptible to plague. Comparison of proliferative, phenotypic, and biochemical properties of fully virulent and vaccine Y. pestis strains demonstrated the advantages of RPMI-1640 medium, which provided extensive in vitro multiplication of the mentioned microorganisms similar to the bacterioemic stage of plague. Using methods of molecular microbiology and immunology, including a panel of monoclonal antibodies, the researchers demonstrated an abrupt fall of production of main plague surface species-specific antigens such as F1, 'murine' toxin/phospholipase D and fibrinolysin, followed by inhibition of biochemical activities associated with these antigenic substances in Y. pestis, as well as specific components of lipopolysaccharide. Possible molecular mechanisms of virulence and adaptive variability of plague bacteria in the extracellular conditions in mammalian organism are discussed.

UI	MeSH Term	Description	Entries
D010587	Phagocytosis	The engulfing and degradation of microorganisms; other cells that are dead, dying, or pathogenic; and foreign particles by phagocytic cells (PHAGOCYTES).	Phagocytoses
D010957	Plasmids	Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.	Episomes,Episome,Plasmid
D002465	Cell Movement	The movement of cells from one location to another. Distinguish from CYTOKINESIS which is the process of dividing the CYTOPLASM of a cell.	Cell Migration,Locomotion, Cell,Migration, Cell,Motility, Cell,Movement, Cell,Cell Locomotion,Cell Motility,Cell Movements,Movements, Cell
D004352	Drug Resistance, Microbial	The ability of microorganisms, especially bacteria, to resist or to become tolerant to chemotherapeutic agents, antimicrobial agents, or antibiotics. This resistance may be acquired through gene mutation or foreign DNA in transmissible plasmids (R FACTORS).	Antibiotic Resistance,Antibiotic Resistance, Microbial,Antimicrobial Resistance, Drug,Antimicrobial Drug Resistance,Antimicrobial Drug Resistances,Antimicrobial Resistances, Drug,Drug Antimicrobial Resistance,Drug Antimicrobial Resistances,Drug Resistances, Microbial,Resistance, Antibiotic,Resistance, Drug Antimicrobial,Resistances, Drug Antimicrobial
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000222	Adaptation, Physiological	The non-genetic biological changes of an organism in response to challenges in its ENVIRONMENT.	Adaptation, Physiologic,Adaptations, Physiologic,Adaptations, Physiological,Adaptive Plasticity,Phenotypic Plasticity,Physiological Adaptation,Physiologic Adaptation,Physiologic Adaptations,Physiological Adaptations,Plasticity, Adaptive,Plasticity, Phenotypic
D015009	Yersinia Infections	Infections with bacteria of the genus YERSINIA.	Yersinia Infection,Infections, Yersinia,Yersinia enterocolitica Infection,Yersiniosis,Infection, Yersinia,Yersinia enterocolitica Infections,Yersinioses
D015010	Yersinia pestis	The etiologic agent of PLAGUE in man, rats, ground squirrels, and other rodents.	Bacillus pestis,Bacterium pestis,Pasteurella pestis,Pestisella pestis,Yersinia pseudotuberculosis subsp. pestis