BIOMAT Database Logo BIOMAT Database Logo

[Hepatotoxicity caused by antituberculosis drugs in pediatrics]. 2005

Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
Departamento de Pediatría del Hospital Nacional Hipólito Unanue.

The clinical profile of hepatotoxicity induced by tuberculosis drugs varies and the re-introduction of therapy for patients who developed this condition is controversial.5 pediatric cases treated throughout a period of 10 years in the Pediatric Department of Hipolito Unanue National Hospital are presented.2 individuals showed an asymptomatic increase of transaminases, 2 individuals had hepatitis, and 1 individual had acute liver failure. Most patients were female school students. Malnutrition and therapy continuation once the hepatic damage was started were found to be the risk factors.A staged reintroduction scheme for these agents after recovery from hepatitis is proposed.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008297 Male Males
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000293 Adolescent A person 13 to 18 years of age. Adolescence,Youth,Adolescents,Adolescents, Female,Adolescents, Male,Teenagers,Teens,Adolescent, Female,Adolescent, Male,Female Adolescent,Female Adolescents,Male Adolescent,Male Adolescents,Teen,Teenager,Youths
D000995 Antitubercular Agents Drugs used in the treatment of tuberculosis. They are divided into two main classes: "first-line" agents, those with the greatest efficacy and acceptable degrees of toxicity used successfully in the great majority of cases; and "second-line" drugs used in drug-resistant cases or those in which some other patient-related condition has compromised the effectiveness of primary therapy. Anti-Tuberculosis Agent,Anti-Tuberculosis Agents,Anti-Tuberculosis Drug,Anti-Tuberculosis Drugs,Antitubercular Agent,Antitubercular Drug,Tuberculostatic Agent,Tuberculostatic Agents,Antitubercular Drugs,Agent, Anti-Tuberculosis,Agent, Antitubercular,Agent, Tuberculostatic,Anti Tuberculosis Agent,Anti Tuberculosis Agents,Anti Tuberculosis Drug,Anti Tuberculosis Drugs,Drug, Anti-Tuberculosis,Drug, Antitubercular
D012189 Retrospective Studies Studies used to test etiologic hypotheses in which inferences about an exposure to putative causal factors are derived from data relating to characteristics of persons under study or to events or experiences in their past. The essential feature is that some of the persons under study have the disease or outcome of interest and their characteristics are compared with those of unaffected persons. Retrospective Study,Studies, Retrospective,Study, Retrospective
D056486 Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment. Drug-Induced Liver Injury,Liver Injury, Drug-Induced,Acute Liver Injury, Drug-Induced,Chemically-Induced Liver Toxicity,Drug-Induced Acute Liver Injury,Drug-Induced Liver Disease,Hepatitis, Drug-Induced,Hepatitis, Toxic,Liver Injury, Drug-Induced, Acute,Toxic Hepatitis,Acute Liver Injury, Drug Induced,Chemically Induced Liver Toxicity,Chemically-Induced Liver Toxicities,Disease, Drug-Induced Liver,Diseases, Drug-Induced Liver,Drug Induced Acute Liver Injury,Drug Induced Liver Disease,Drug Induced Liver Injury,Drug-Induced Hepatitides,Drug-Induced Hepatitis,Drug-Induced Liver Diseases,Drug-Induced Liver Injuries,Hepatitides, Drug-Induced,Hepatitides, Toxic,Hepatitis, Drug Induced,Injuries, Drug-Induced Liver,Injury, Drug-Induced Liver,Liver Disease, Drug-Induced,Liver Diseases, Drug-Induced,Liver Injuries, Drug-Induced,Liver Injury, Drug Induced,Liver Toxicities, Chemically-Induced,Liver Toxicity, Chemically-Induced,Toxic Hepatitides,Toxicities, Chemically-Induced Liver,Toxicity, Chemically-Induced Liver

Related Publications

Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
Antituberculosis drugs and hepatotoxicity.
April 2007, American journal of respiratory and critical care medicine,
Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
Antituberculosis drugs and hepatotoxicity.
June 2004, Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases,
Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
Antituberculosis drugs and hepatotoxicity.
November 2006, Respirology (Carlton, Vic.),
Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
Hepatotoxicity of antituberculosis drugs.
August 1996, Thorax,
Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
Hepatotoxicity of antituberculosis drugs.
November 1996, Thorax,
Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
Hepatotoxicity of antituberculosis drugs.
February 1996, Thorax,
Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
Risk factors for hepatotoxicity induced by antituberculosis drugs.
January 1997, Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia,
Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
Hepatotoxicity caused by drugs.
July 1988, Rational drug therapy,
Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
[Hepatotoxicity of antituberculosis drugs: practical implications for monitoring].
February 1998, Gastroenterologie clinique et biologique,
Luz Victoria Reto Valiente, and José Castillo Vergara, and Patricia Pichilingue Reto, and Oscar Alfredo Pichilingue Prieto
Cutaneous adverse drug reactions caused by antituberculosis drugs.
January 2014, Inflammation & allergy drug targets,
Copied contents to your clipboard!