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Chromosome fragile sites are inducible by aphidicolin in cultured human lymphocytes. To assess the frequency and distribution of these common fragile sites in the general population, a cytogenetic survey was performed on 126 subjects, 59 males and 67 females, whose age ranged from 1 day to 72 years. Common fragile sites, induced by aphidicolin, were widespread and showed a remarkably different sensitivity among individuals; age influenced the overall frequency of fragile sites. Moreover, both age and sex seemed to modulate the expression of specific fragile sites. In our population, the most common fragile sites were: 3p14, 16q23, Xp22, 6q26, 1p31, 4q31, 1p22, 7q22, 2q33, 3q27, 2q31, 7q32, 14q24, 10q22, 5q31, 2q37, 6p21.
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Clinical genetics,
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February 1986,
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December 1988,
Human genetics,
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Human genetics,
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February 1988,
Human genetics,
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January 1996,
American journal of human biology : the official journal of the Human Biology Council,
B Tedeschi, and
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February 1988,
Human genetics,
B Tedeschi, and
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B Nicoletti
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Human genetics,
B Tedeschi, and
P Vernole, and
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B Nicoletti
May 1985,
Annals of human genetics,
