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The effect of several flavanolignans (silicristin, silidianin, silybin and isosilybin) present in silymarin, the extract of Silybum marianum fruits, was tested on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes. In microsomes lipid peroxidation was generated by ADP/Fe2+ and NADPH. All flavanolignans inhibited peroxidation in a concentration dependent manner. In hepatocytes lipid peroxidation was induced by ADP/Fe3+ complex and cell damage was evaluated as LDH activity released in the medium. The inhibition of the peroxidative process by flavanolignans was also evident in this model, even if with a potency order different from that found in microsomes. In contrast, the effect on LDH release was significant only for silybin and isosilybin, the other compounds being inactive on this parameter.
E Bosisio, and
C Benelli, and
O Pirola
January 2005,
Phytochemical analysis : PCA,
E Bosisio, and
C Benelli, and
O Pirola
November 1983,
Biochemical pharmacology,
E Bosisio, and
C Benelli, and
O Pirola
January 1989,
Chemico-biological interactions,
E Bosisio, and
C Benelli, and
O Pirola
February 1988,
Nihon juigaku zasshi. The Japanese journal of veterinary science,
E Bosisio, and
C Benelli, and
O Pirola
January 1981,
Bulletin europeen de physiopathologie respiratoire,
E Bosisio, and
C Benelli, and
O Pirola
August 1976,
Hoppe-Seyler's Zeitschrift fur physiologische Chemie,
E Bosisio, and
C Benelli, and
O Pirola
January 2001,
Eksperimental'naia i klinicheskaia farmakologiia,
E Bosisio, and
C Benelli, and
O Pirola
April 1971,
Nordisk medicin,
E Bosisio, and
C Benelli, and
O Pirola
December 1980,
Biochimica et biophysica acta,
E Bosisio, and
C Benelli, and
O Pirola
January 1971,
Acta pathologica et microbiologica Scandinavica. Section A, Pathology,
