The influence of caffeine on nicotine's discriminative stimulus, subjective, and reinforcing effects. 2005

Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
Department of Psychiatry, University of Pittsburgh School of Medicine, PA 15213, USA. perkinska@upmc.edu

Caffeine may acutely alter the discriminative stimulus and subjective effects of nicotine, perhaps explaining the association of coffee intake with smoking status. In this study, smokers were initially trained to discriminate 20 microg/kg nicotine by nasal spray from placebo (0). Then, generalization of nicotine discrimination was tested, using both 2- and 3-choice ("novel" option) procedures, across a range of doses (0-20 microg/kg) following pretreatment with 0, 2.5, and 5.0 mg/kg caffeine p.o. Nicotine reinforcement was assessed after the end of generalization testing using a choice procedure. Caffeine pretreatment did not alter nicotine discrimination and self-administration. Caffeine and nicotine influenced some subjective and cardiovascular responses, but there were no interaction effects except for diastolic blood pressure. These results do not support the notion that caffeine acutely alters nicotine's discriminative stimulus, subjective, or reinforcing effects.

UI MeSH Term Description Entries
D008297 Male Males
D009538 Nicotine Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke. Nicotine Bitartrate,Nicotine Tartrate
D012054 Reinforcement, Psychology The strengthening of a conditioned response. Negative Reinforcement,Positive Reinforcement,Psychological Reinforcement,Reinforcement (Psychology),Negative Reinforcements,Positive Reinforcements,Psychological Reinforcements,Psychology Reinforcement,Psychology Reinforcements,Reinforcement, Negative,Reinforcement, Positive,Reinforcement, Psychological,Reinforcements (Psychology),Reinforcements, Negative,Reinforcements, Positive,Reinforcements, Psychological,Reinforcements, Psychology
D001794 Blood Pressure PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS. Systolic Pressure,Diastolic Pressure,Pulse Pressure,Pressure, Blood,Pressure, Diastolic,Pressure, Pulse,Pressure, Systolic,Pressures, Systolic
D002110 Caffeine A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling. 1,3,7-Trimethylxanthine,Caffedrine,Coffeinum N,Coffeinum Purrum,Dexitac,Durvitan,No Doz,Percoffedrinol N,Percutaféine,Quick-Pep,Vivarin,Quick Pep,QuickPep
D004192 Discrimination, Psychological Differential response to different stimuli. Discrimination, Psychology,Psychological Discrimination
D004193 Discrimination Learning Learning that is manifested in the ability to respond differentially to various stimuli. Discriminative Learning,Discrimination Learnings,Discriminative Learnings,Learning, Discrimination,Learning, Discriminative
D004305 Dose-Response Relationship, Drug The relationship between the dose of an administered drug and the response of the organism to the drug. Dose Response Relationship, Drug,Dose-Response Relationships, Drug,Drug Dose-Response Relationship,Drug Dose-Response Relationships,Relationship, Drug Dose-Response,Relationships, Drug Dose-Response
D004334 Drug Administration Schedule Time schedule for administration of a drug in order to achieve optimum effectiveness and convenience. Administration Schedule, Drug,Administration Schedules, Drug,Drug Administration Schedules,Schedule, Drug Administration,Schedules, Drug Administration
D004347 Drug Interactions The action of a drug that may affect the activity, metabolism, or toxicity of another drug. Drug Interaction,Interaction, Drug,Interactions, Drug

Related Publications

Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
June 1994, Psychopharmacology,
Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
March 1997, Psychopharmacology,
Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
April 1991, Behavioural pharmacology,
Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
November 1997, Drug and alcohol dependence,
Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
January 1989, NIDA research monograph,
Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
November 2023, Pharmacology, biochemistry, and behavior,
Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
March 1996, Behavioural pharmacology,
Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
October 1996, Psychopharmacology,
Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
March 1982, Pharmacology, biochemistry, and behavior,
Kenneth A Perkins, and Carolyn Fonte, and Amy Stolinski, and Richard Blakesley-Ball, and Annette S Wilson
March 2019, Psychopharmacology,
Copied contents to your clipboard!