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A clinical trial of the oral form of VP 16-213 (NSC-141540), a semisynthetic podophyllotoxin, was undertaken. In 20 patients, treatment was started at 200 mg/day p.o. for 5 days; courses were repeated after a rest period of 16 days. Five patients were treated at the same dose, repeated with only 9-day rest periods. Subsequently, 65 patients were given 300-400 mg/day for 5 days, with rest periods of 9 days between courses. The side effects encountered included anorexia, nausea and vomiting, stomatitis, diarrhea, leukopenia, thrombocytopenia, alopecia, and pruritus. Substernal discomfort with or without palpitations was reported by 18 patients; no explanation for this symptom could be found. No complete remissions (CR) were observed. Parital remissions (PR) and improvement (IMP) were seen as follows: small cell carcinoma, lung (10 patients)--2 PR, 3 IMP; adenocarcinoma, lung (4 patients)--1 PR; alveolar cell carcinoma, lung (1 patient)--1 IMP; mesothelioma (4 patients)--1 IMP; ovarian cancer (12 patients)--3 PR, 3 IMP; breast cancer (20 patients)--4 IMP; colon cancer (8 patients)--2 IMP; bladder cancer (4 patients)--2 IMP; histiocytic lymphoma (7 patients)--2 PR, 3 IMP; chronic myeloid leukemia (1 patient)--1 IMP.
G Falkson, and
J J van Dyk, and
E B van Eden, and
A M van der Merwe, and
J A van den Bergh, and
H C Falkson
January 1974,
Cancer chemotherapy reports,
G Falkson, and
J J van Dyk, and
E B van Eden, and
A M van der Merwe, and
J A van den Bergh, and
H C Falkson
December 1972,
Cancer chemotherapy reports,
G Falkson, and
J J van Dyk, and
E B van Eden, and
A M van der Merwe, and
J A van den Bergh, and
H C Falkson
March 1976,
European journal of cancer,
G Falkson, and
J J van Dyk, and
E B van Eden, and
A M van der Merwe, and
J A van den Bergh, and
H C Falkson
January 1975,
Cancer chemotherapy reports,
G Falkson, and
J J van Dyk, and
E B van Eden, and
A M van der Merwe, and
J A van den Bergh, and
H C Falkson
January 1981,
Journal of chromatography,
G Falkson, and
J J van Dyk, and
E B van Eden, and
A M van der Merwe, and
J A van den Bergh, and
H C Falkson
August 1978,
Cancer research,
G Falkson, and
J J van Dyk, and
E B van Eden, and
A M van der Merwe, and
J A van den Bergh, and
H C Falkson
August 1977,
Cancer,
G Falkson, and
J J van Dyk, and
E B van Eden, and
A M van der Merwe, and
J A van den Bergh, and
H C Falkson
January 1975,
Cancer chemotherapy reports,
G Falkson, and
J J van Dyk, and
E B van Eden, and
A M van der Merwe, and
J A van den Bergh, and
H C Falkson
March 1974,
La Nouvelle presse medicale,
G Falkson, and
J J van Dyk, and
E B van Eden, and
A M van der Merwe, and
J A van den Bergh, and
H C Falkson
January 1975,
Cancer chemotherapy reports,
