-transparent.png){kind=logo}
The purpose of this study was to develop an artificial baroreceptor that was capable of invoking the "natural" baroreflex by electrically stimulating the afferent nerve. In six anesthetized, vagotomized dogs, we first identified, using the white-noise method, the transfer function from carotid sinus pressure to aortic pressure (HCSP.AoP) and that from the electrical carotid sinus nerve stimulation to aortic pressure (HCSN.AoP). We then backcalculated the transfer function required for the artificial baroreceptor (HCSP.CSN) as the ratio of HCSP.AoP to HCSN.AoP. To activate the artificial baroreceptor, we electrically stimulated the carotid sinus nerve with the frequency-modulated pulse train obtained in real time by convolving the impulse response of HCSP.CSN with instantaneous aortic pressure. We tested performance of the artificial baroreceptor by imposing random changes in blood volume. The pressure-stabilizing effects of the artificial baroreceptor were indistinguishable from those of the native one. We conclude that the artificial baroreceptor can invoke the natural baroreflex. The proposed framework generally would be applicable to interface artificial devices with the central nervous system.
T Kubota, and
H Chishaki, and
T Yoshida, and
K Sunagawa, and
A Takeshita, and
Y Nose
September 2008,
American journal of physiology. Heart and circulatory physiology,
T Kubota, and
H Chishaki, and
T Yoshida, and
K Sunagawa, and
A Takeshita, and
Y Nose
September 1993,
The American journal of physiology,
T Kubota, and
H Chishaki, and
T Yoshida, and
K Sunagawa, and
A Takeshita, and
Y Nose
December 1981,
The American journal of physiology,
T Kubota, and
H Chishaki, and
T Yoshida, and
K Sunagawa, and
A Takeshita, and
Y Nose
October 2017,
Journal of applied physiology (Bethesda, Md. : 1985),
T Kubota, and
H Chishaki, and
T Yoshida, and
K Sunagawa, and
A Takeshita, and
Y Nose
July 1979,
The Journal of physiology,
T Kubota, and
H Chishaki, and
T Yoshida, and
K Sunagawa, and
A Takeshita, and
Y Nose
December 2017,
Life sciences,
T Kubota, and
H Chishaki, and
T Yoshida, and
K Sunagawa, and
A Takeshita, and
Y Nose
May 1983,
Clinical science (London, England : 1979),
T Kubota, and
H Chishaki, and
T Yoshida, and
K Sunagawa, and
A Takeshita, and
Y Nose
December 1996,
The American journal of physiology,
T Kubota, and
H Chishaki, and
T Yoshida, and
K Sunagawa, and
A Takeshita, and
Y Nose
January 1971,
Acta physiologica Scandinavica,
T Kubota, and
H Chishaki, and
T Yoshida, and
K Sunagawa, and
A Takeshita, and
Y Nose
April 1993,
The American journal of physiology,
