BIOMAT Database Logo BIOMAT Database Logo

Blastomogenic activity of p-hydroxyphenyllactic acid in mice. 1975

M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova

Blastomogenic activity of p-hydroxyphenyllactic acid was established by prolonged s.c. administration into C57BL/6 and CC57BR mice. Phenyllactic acid was also tested and was not blastomogenic under the same conditions. The preparations in aqueous solutions were injected into the dorsal region twice weekly in 1.5-mg doses. The total dose per mouse was 42 mg p-hydroxyphenyllactic acid or 50 mg phenyllactic acid. The resorptive character and many forms of blastomogenic activity of p-hydroxphenyllactic acid were shown. It induced neoplasms of varied histogenesis (leukemias, adenomas, hepatomas, and tumors of the vascular tissue),including benign and malignant tumors and precancerous conditions of the urniary bladder.

UI MeSH Term Description Entries
D007942 Leukemia, Experimental Leukemia induced experimentally in animals by exposure to leukemogenic agents, such as VIRUSES; RADIATION; or by TRANSPLANTATION of leukemic tissues. Experimental Leukemia,Experimental Leukemias,Leukemia Model, Animal,Leukemias, Experimental,Animal Leukemia Model,Animal Leukemia Models,Leukemia Models, Animal
D008113 Liver Neoplasms Tumors or cancer of the LIVER. Cancer of Liver,Hepatic Cancer,Liver Cancer,Cancer of the Liver,Cancer, Hepatocellular,Hepatic Neoplasms,Hepatocellular Cancer,Neoplasms, Hepatic,Neoplasms, Liver,Cancer, Hepatic,Cancer, Liver,Cancers, Hepatic,Cancers, Hepatocellular,Cancers, Liver,Hepatic Cancers,Hepatic Neoplasm,Hepatocellular Cancers,Liver Cancers,Liver Neoplasm,Neoplasm, Hepatic,Neoplasm, Liver
D008810 Mice, Inbred C57BL One of the first INBRED MOUSE STRAINS to be sequenced. This strain is commonly used as genetic background for transgenic mouse models. Refractory to many tumors, this strain is also preferred model for studying role of genetic variations in development of diseases. Mice, C57BL,Mouse, C57BL,Mouse, Inbred C57BL,C57BL Mice,C57BL Mice, Inbred,C57BL Mouse,C57BL Mouse, Inbred,Inbred C57BL Mice,Inbred C57BL Mouse
D009374 Neoplasms, Experimental Experimentally induced new abnormal growth of TISSUES in animals to provide models for studying human neoplasms. Experimental Neoplasms,Experimental Neoplasm,Neoplasm, Experimental
D010648 Phenylacetates Derivatives of phenylacetic acid. Included under this heading are a variety of acid forms, salts, esters, and amides that contain the benzeneacetic acid structure. Note that this class of compounds should not be confused with derivatives of phenyl acetate, which contain the PHENOL ester of ACETIC ACID. Benzeneacetates,Benzeneacetic Acids,Phenylacetic Acids,Acids, Benzeneacetic,Acids, Phenylacetic
D011230 Precancerous Conditions Pathological conditions that tend eventually to become malignant. Preneoplastic Conditions,Condition, Preneoplastic,Conditions, Preneoplastic,Preneoplastic Condition,Condition, Precancerous,Conditions, Precancerous,Precancerous Condition
D001749 Urinary Bladder Neoplasms Tumors or cancer of the URINARY BLADDER. Bladder Cancer,Bladder Neoplasms,Cancer of Bladder,Bladder Tumors,Cancer of the Bladder,Malignant Tumor of Urinary Bladder,Neoplasms, Bladder,Urinary Bladder Cancer,Bladder Cancers,Bladder Neoplasm,Bladder Tumor,Cancer, Bladder,Cancer, Urinary Bladder,Neoplasm, Bladder,Neoplasm, Urinary Bladder,Tumor, Bladder,Tumors, Bladder,Urinary Bladder Neoplasm
D002273 Carcinogens Substances that increase the risk of NEOPLASMS in humans or animals. Both genotoxic chemicals, which affect DNA directly, and nongenotoxic chemicals, which induce neoplasms by other mechanism, are included. Carcinogen,Oncogen,Oncogens,Tumor Initiator,Tumor Initiators,Tumor Promoter,Tumor Promoters,Initiator, Tumor,Initiators, Tumor,Promoter, Tumor,Promoters, Tumor
D006528 Carcinoma, Hepatocellular A primary malignant neoplasm of epithelial liver cells. It ranges from a well-differentiated tumor with EPITHELIAL CELLS indistinguishable from normal HEPATOCYTES to a poorly differentiated neoplasm. The cells may be uniform or markedly pleomorphic, or form GIANT CELLS. Several classification schemes have been suggested. Hepatocellular Carcinoma,Hepatoma,Liver Cancer, Adult,Liver Cell Carcinoma,Liver Cell Carcinoma, Adult,Adult Liver Cancer,Adult Liver Cancers,Cancer, Adult Liver,Cancers, Adult Liver,Carcinoma, Liver Cell,Carcinomas, Hepatocellular,Carcinomas, Liver Cell,Cell Carcinoma, Liver,Cell Carcinomas, Liver,Hepatocellular Carcinomas,Hepatomas,Liver Cancers, Adult,Liver Cell Carcinomas
D000236 Adenoma A benign epithelial tumor with a glandular organization. Adenoma, Basal Cell,Adenoma, Follicular,Adenoma, Microcystic,Adenoma, Monomorphic,Adenoma, Papillary,Adenoma, Trabecular,Adenomas,Adenomas, Basal Cell,Adenomas, Follicular,Adenomas, Microcystic,Adenomas, Monomorphic,Adenomas, Papillary,Adenomas, Trabecular,Basal Cell Adenoma,Basal Cell Adenomas,Follicular Adenoma,Follicular Adenomas,Microcystic Adenoma,Microcystic Adenomas,Monomorphic Adenoma,Monomorphic Adenomas,Papillary Adenoma,Papillary Adenomas,Trabecular Adenoma,Trabecular Adenomas

Related Publications

M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova
[Local manifestation of the blastomogenic activity of p-hydroxyphenyllactic acid].
February 1983, Gematologiia i transfuziologiia,
M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova
[Mechanism of formation of the blastomogenic metabolite of tyrosine - P-hydroxyphenyllactic acid in hemoblastoses].
May 1978, Problemy gematologii i perelivaniia krovi,
M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova
[Excretion of the blastomogenic tyrosine metabolite, p-hydroxyphenyllactic acid, in young children with hemoblastoses and their parents].
April 1981, Problemy gematologii i perelivaniia krovi,
M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova
[The effect of d,1-diiodo-p-hydroxyphenyllactic acid and d,1-dibromo-p-hydroxyphenyllactic acid on thyroidin creatinuria].
January 1951, Zeitschrift fur die gesamte experimentelle Medizin,
M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova
[Immunomodulating activity of p-hydroxyphenyllactic and ascorbic acids].
March 1984, Biulleten' eksperimental'noi biologii i meditsiny,
M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova
Abnormal urinary excretion of p-hydroxyphenyllactic acid in Wilms' tumor.
November 1968, Clinica chimica acta; international journal of clinical chemistry,
M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova
[Transplacental blastomogenic effect of p-hydroxyphenyl lactic acid].
January 1979, Biulleten' eksperimental'noi biologii i meditsiny,
M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova
Facile synthesis of optically pure (S)-3-p-hydroxyphenyllactic acid derivatives.
September 2007, Amino acids,
M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova
[Leukogenic (blastomogenic) activity of 3-indolylacrylic acid].
June 1973, Problemy gematologii i perelivaniia krovi,
M O Rauschenbach, and E I Zharova, and T I Sergeeva, and V D Ivanova, and N A Probatova
[Blastomogenic activity of 3-hydroxyanthranilic acid in dogs].
January 1980, Voprosy onkologii,
Copied contents to your clipboard!