BIOMAT Database Logo BIOMAT Database Logo

Evidence that calcitonin gene-related peptide contributes to inflammation in the skin and joint. 1992

S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
Biomedical Sciences Division, King's College, London, United Kingdom.

Calcitonin gene-related peptide produces dose-related vasodilatation after intradermal injection in several species. In the present study, CGRP increased blood flow in rabbit skin but had no direct effect on edema formation in rat or rabbit skin or in the rat knee joint. However, CGRP produced significant potentiation of edema formation when co-injected with histamine, a potent mediator of increased vascular permeability. Therefore, release of CGRP from stimulated C-fiber nerves may contribute to the vascular changes that are an integral part of the inflammatory process. The activity of the putative CGRP antagonist CGRP8-37 (300 pmol) against CGRP was also investigated in rabbit and rat skin. Whereas it was found to selectively antagonize the effects of CGRP in rabbit skin, the antagonist produced edema in rat skin at the same dose. Thus, CGRP8-37 may be used in the rabbit to study the effects of endogenously released CGRP, but caution is required when this antagonist is used in the rat.

UI MeSH Term Description Entries
D007249 Inflammation A pathological process characterized by injury or destruction of tissues caused by a variety of cytologic and chemical reactions. It is usually manifested by typical signs of pain, heat, redness, swelling, and loss of function. Innate Inflammatory Response,Inflammations,Inflammatory Response, Innate,Innate Inflammatory Responses
D007457 Iodine Radioisotopes Unstable isotopes of iodine that decay or disintegrate emitting radiation. I atoms with atomic weights 117-139, except I 127, are radioactive iodine isotopes. Radioisotopes, Iodine
D007592 Joint Diseases Diseases involving the JOINTS. Arthropathies,Arthropathy,Joint Disease
D008297 Male Males
D011919 Rats, Inbred Strains Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding. August Rats,Inbred Rat Strains,Inbred Strain of Rat,Inbred Strain of Rats,Inbred Strains of Rats,Rat, Inbred Strain,August Rat,Inbred Rat Strain,Inbred Strain Rat,Inbred Strain Rats,Inbred Strains Rat,Inbred Strains Rats,Rat Inbred Strain,Rat Inbred Strains,Rat Strain, Inbred,Rat Strains, Inbred,Rat, August,Rat, Inbred Strains,Rats Inbred Strain,Rats Inbred Strains,Rats, August,Rats, Inbred Strain,Strain Rat, Inbred,Strain Rats, Inbred,Strain, Inbred Rat,Strains, Inbred Rat
D012039 Regional Blood Flow The flow of BLOOD through or around an organ or region of the body. Blood Flow, Regional,Blood Flows, Regional,Flow, Regional Blood,Flows, Regional Blood,Regional Blood Flows
D004487 Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE. Dropsy,Hydrops,Anasarca
D006632 Histamine An amine derived by enzymatic decarboxylation of HISTIDINE. It is a powerful stimulant of gastric secretion, a constrictor of bronchial smooth muscle, a vasodilator, and also a centrally acting neurotransmitter. Ceplene,Histamine Dihydrochloride,Histamine Hydrochloride,Peremin
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000818 Animals Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA. Animal,Metazoa,Animalia

Related Publications

S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
Calcitonin gene-related peptide in the joint: contributions to pain and inflammation.
November 2015, British journal of clinical pharmacology,
S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
Evidence that calcitonin gene-related peptide contributes to the capsaicin-induced relaxation of guinea pig cerebral arteries.
December 1990, Regulatory peptides,
S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
Calcitonin gene-related peptide improves skin flap survival and tissue inflammation.
June 1998, Neuropeptides,
S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
[Regulatory mechanisms of calcitonin gene-related peptide (CGRP) in skin inflammation].
January 2012, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
Pharmacological evidence that calcitonin gene-related peptide is implicated in cerebral autoregulation.
January 1994, The American journal of physiology,
S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
Calcitonin gene-related peptide: possibly neurotransmitter contributes to penile erection in monkeys.
April 1993, Urology,
S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
Calcitonin gene-related peptide contributes to the umbilical haemodynamic defence response to acute hypoxaemia.
February 2005, The Journal of physiology,
S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
Substance P and calcitonin gene-related peptide (CGRP) in gastrointestinal inflammation.
January 1992, Annals of the New York Academy of Sciences,
S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
Evidence that alpha-calcitonin gene-related peptide is a neurohormone that controls systemic lipid availability and utilization.
January 2008, Endocrinology,
S D Brain, and H Cambridge, and S R Hughes, and P Wilsoncroft
Vasoactive properties of calcitonin gene-related peptide in human skin.
October 2011, International angiology : a journal of the International Union of Angiology,
Copied contents to your clipboard!