BIOMAT Database Logo BIOMAT Database Logo

Biological studies of photoinducible phenol quaternary ammonium derivatives. 2006

Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
College of Chemistry and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, PR China.

Three water-soluble DNA cross-linking phenol quaternary ammonium derivatives 3, 4, and 5 could inhibit the transcription in vitro by photoactivation. DNA interstrand cross-linking action might be the key factor to inhibit transcription by these compounds. Further tumor cell apoptosis was observed by flow cytometry it indicated that cross-linking agent 5 could significantly induce the late apoptosis of tumor cells.

UI MeSH Term Description Entries
D008027 Light That portion of the electromagnetic spectrum in the visible, ultraviolet, and infrared range. Light, Visible,Photoradiation,Radiation, Visible,Visible Radiation,Photoradiations,Radiations, Visible,Visible Light,Visible Radiations
D010636 Phenols Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.
D003432 Cross-Linking Reagents Reagents with two reactive groups, usually at opposite ends of the molecule, that are capable of reacting with and thereby forming bridges between side chains of amino acids in proteins; the locations of naturally reactive areas within proteins can thereby be identified; may also be used for other macromolecules, like glycoproteins, nucleic acids, or other. Bifunctional Reagent,Bifunctional Reagents,Cross Linking Reagent,Crosslinking Reagent,Cross Linking Reagents,Crosslinking Reagents,Linking Reagent, Cross,Linking Reagents, Cross,Reagent, Bifunctional,Reagent, Cross Linking,Reagent, Crosslinking,Reagents, Bifunctional,Reagents, Cross Linking,Reagents, Cross-Linking,Reagents, Crosslinking
D004247 DNA A deoxyribonucleotide polymer that is the primary genetic material of all cells. Eukaryotic and prokaryotic organisms normally contain DNA in a double-stranded state, yet several important biological processes transiently involve single-stranded regions. DNA, which consists of a polysugar-phosphate backbone possessing projections of purines (adenine and guanine) and pyrimidines (thymine and cytosine), forms a double helix that is held together by hydrogen bonds between these purines and pyrimidines (adenine to thymine and guanine to cytosine). DNA, Double-Stranded,Deoxyribonucleic Acid,ds-DNA,DNA, Double Stranded,Double-Stranded DNA,ds DNA
D005434 Flow Cytometry Technique using an instrument system for making, processing, and displaying one or more measurements on individual cells obtained from a cell suspension. Cells are usually stained with one or more fluorescent dyes specific to cell components of interest, e.g., DNA, and fluorescence of each cell is measured as it rapidly transverses the excitation beam (laser or mercury arc lamp). Fluorescence provides a quantitative measure of various biochemical and biophysical properties of the cell, as well as a basis for cell sorting. Other measurable optical parameters include light absorption and light scattering, the latter being applicable to the measurement of cell size, shape, density, granularity, and stain uptake. Cytofluorometry, Flow,Cytometry, Flow,Flow Microfluorimetry,Fluorescence-Activated Cell Sorting,Microfluorometry, Flow,Cell Sorting, Fluorescence-Activated,Cell Sortings, Fluorescence-Activated,Cytofluorometries, Flow,Cytometries, Flow,Flow Cytofluorometries,Flow Cytofluorometry,Flow Cytometries,Flow Microfluorometries,Flow Microfluorometry,Fluorescence Activated Cell Sorting,Fluorescence-Activated Cell Sortings,Microfluorimetry, Flow,Microfluorometries, Flow,Sorting, Fluorescence-Activated Cell,Sortings, Fluorescence-Activated Cell
D000644 Quaternary Ammonium Compounds Derivatives of ammonium compounds, NH4+ Y-, in which all four of the hydrogens bonded to nitrogen have been replaced with hydrocarbyl groups. These are distinguished from IMINES which are RN Quaternary Ammonium Compound,Ammonium Compound, Quaternary,Ammonium Compounds, Quaternary,Compound, Quaternary Ammonium
D014158 Transcription, Genetic The biosynthesis of RNA carried out on a template of DNA. The biosynthesis of DNA from an RNA template is called REVERSE TRANSCRIPTION. Genetic Transcription
D017209 Apoptosis A regulated cell death mechanism characterized by distinctive morphologic changes in the nucleus and cytoplasm, including the endonucleolytic cleavage of genomic DNA, at regularly spaced, internucleosomal sites, i.e., DNA FRAGMENTATION. It is genetically programmed and serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. Apoptosis, Extrinsic Pathway,Apoptosis, Intrinsic Pathway,Caspase-Dependent Apoptosis,Classic Apoptosis,Classical Apoptosis,Programmed Cell Death,Programmed Cell Death, Type I,Apoptoses, Extrinsic Pathway,Apoptoses, Intrinsic Pathway,Apoptosis, Caspase-Dependent,Apoptosis, Classic,Apoptosis, Classical,Caspase Dependent Apoptosis,Cell Death, Programmed,Classic Apoptoses,Extrinsic Pathway Apoptoses,Extrinsic Pathway Apoptosis,Intrinsic Pathway Apoptoses,Intrinsic Pathway Apoptosis

Related Publications

Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
Synthesis and biological activities of quinazoline derivatives with ortho-phenol-quaternary ammonium salt groups.
November 2007, Bioorganic & medicinal chemistry,
Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
Biological Activity of Quaternary Ammonium Salts and Their Derivatives.
June 2020, Pathogens (Basel, Switzerland),
Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
Quaternary ammonium derivatives of omega-amino acids a new series of quaternary ammonium compounds.
May 1953, Applied microbiology,
Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
Quaternary ammonium salts as germicides; acetoxy and carbethoxy derivatives of aliphatic quaternary ammonium salts.
May 1946, Journal of the American Chemical Society,
Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
[Synthesis and biological activity of substituted benzyl/naphthylmethylisoquinolines and related quaternary ammonium derivatives].
January 1994, Yao xue xue bao = Acta pharmaceutica Sinica,
Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
[Central effects of gangliolytic quaternary ammonium derivatives].
January 1961, Farmakologiia i toksikologiia,
Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
Interaction of quaternary ammonium bactericides with biological materials. II. Insoluble monolayer studies.
March 1972, Journal of pharmaceutical sciences,
Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
[Interaction between acyclic phenol--formaldehyde oligomers and quaternary ammonium ions].
June 2002, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan,
Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
Quaternary ammonium salts of arylaliphatic derivatives; curary properties.
February 1949, Comptes rendus hebdomadaires des seances de l'Academie des sciences,
Yang Song, and Ping Wang, and Juanjuan Wu, and Xiang Zhou, and Xiao-Lian Zhang, and Linhong Weng, and Xiaoping Cao, and Feng Liang
QUATERNARY DERIVATIVES OF AMINOACYLANILINES. 3. BISQUATERNARY AMMONIUM SALTS.
June 1965, Acta pharmaceutica Suecica,
Copied contents to your clipboard!