P3 from auditory stimuli in healthy elderly subjects: hearing threshold and tone stimulus frequency. 1992

V E Pollock, and L S Schneider
Department of Psychiatry and Behavioral Sciences, University of Southern California School of Medicine, Los Angeles 90033.

The P3 event-related potential (ERP) was elicited by auditory stimuli under two conditions: (1) 250 Hz standard, 500 Hz target; and, (2) 1000 Hz standard, 2000 Hz target. A group with normal hearing (n = 10), defined as subjects with less than a 16 dB loss at each tone frequency was compared to a group with hearing impairment (n = 8), defined as subjects with a loss of 16 dB or more at each tone frequency. The hearing impaired group showed significant P3 latency prolongations compared to those with normal hearing under the 2000 Hz, but not the 500 Hz target, even though subject age was used as a covariate. Under both conditions, hearing impaired subjects showed reduced P3 amplitudes compared to those with normal hearing. These findings are discussed in relation to the sensitivity of ERP assessment procedures in older adults.

UI MeSH Term Description Entries
D008297 Male Males
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D005072 Evoked Potentials, Auditory The electric response evoked in the CEREBRAL CORTEX by ACOUSTIC STIMULATION or stimulation of the AUDITORY PATHWAYS. Auditory Evoked Potentials,Auditory Evoked Response,Auditory Evoked Potential,Auditory Evoked Responses,Evoked Potential, Auditory,Evoked Response, Auditory,Evoked Responses, Auditory,Potentials, Auditory Evoked
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000161 Acoustic Stimulation Use of sound to elicit a response in the nervous system. Auditory Stimulation,Stimulation, Acoustic,Stimulation, Auditory
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D000375 Aging The gradual irreversible changes in structure and function of an organism that occur as a result of the passage of time. Senescence,Aging, Biological,Biological Aging
D001309 Auditory Threshold The audibility limit of discriminating sound intensity and pitch. Auditory Thresholds,Threshold, Auditory,Thresholds, Auditory

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