Role of LPS-stimulated human monocyte-derived dendritic cells in the modulation of autologous CD4+ CD25+ T Cell activation. 2005

Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
Division of Cellular and Molecular Pathology, Department of Cellular Function, Niigata University, Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan. liujiwei@medmail.com.cn

Dendritic cells (DC) are now recognized as the most potent professional antigen presenting cells (APC). Several studies on cancer immunotherapy using different approaches to induce cytotoxic T lymphocytes (CTL) in vivo recognizing tumor-associated antigens have been reported. However, the efficacy of immunotherapy in vivo may be limited by the local or systemic suppression of CTL generation or function. To explore the ability of lipopolysaccharide (LPS) stimulated human monocyte-derived DC involved in activity of autologous CD4(+)CD25(+) T cells, HLA-A2 restricted p53(264 - 272) peptide was used as tumor antigen, DC generated with LPS (DC-LPS(+)) or without LPS (DC-LPS(-)) were co-cultured with autologous T cells respectively. The results showed that CD4(+)CD25(+) T cell population in the DC-LPS(+) activated T cells was lower than that in the DC-LPS(-) activated T cells. This finding suggest that the relationship between DC-LPS(+) and population of CD4(+)CD25(+) T cells exists and this property may contribute to regulation of T cell responses to tumor-associated antigens.

UI MeSH Term Description Entries
D008070 Lipopolysaccharides Lipid-containing polysaccharides which are endotoxins and important group-specific antigens. They are often derived from the cell wall of gram-negative bacteria and induce immunoglobulin secretion. The lipopolysaccharide molecule consists of three parts: LIPID A, core polysaccharide, and O-specific chains (O ANTIGENS). When derived from Escherichia coli, lipopolysaccharides serve as polyclonal B-cell mitogens commonly used in laboratory immunology. (From Dorland, 28th ed) Lipopolysaccharide,Lipoglycans
D008213 Lymphocyte Activation Morphologic alteration of small B LYMPHOCYTES or T LYMPHOCYTES in culture into large blast-like cells able to synthesize DNA and RNA and to divide mitotically. It is induced by INTERLEUKINS; MITOGENS such as PHYTOHEMAGGLUTININS, and by specific ANTIGENS. It may also occur in vivo as in GRAFT REJECTION. Blast Transformation,Blastogenesis,Lymphoblast Transformation,Lymphocyte Stimulation,Lymphocyte Transformation,Transformation, Blast,Transformation, Lymphoblast,Transformation, Lymphocyte,Activation, Lymphocyte,Stimulation, Lymphocyte
D009000 Monocytes Large, phagocytic mononuclear leukocytes produced in the vertebrate BONE MARROW and released into the BLOOD; contain a large, oval or somewhat indented nucleus surrounded by voluminous cytoplasm and numerous organelles. Monocyte
D002454 Cell Differentiation Progressive restriction of the developmental potential and increasing specialization of function that leads to the formation of specialized cells, tissues, and organs. Differentiation, Cell,Cell Differentiations,Differentiations, Cell
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D003713 Dendritic Cells Specialized cells of the hematopoietic system that have branch-like extensions. They are found throughout the lymphatic system, and in non-lymphoid tissues such as SKIN and the epithelia of the intestinal, respiratory, and reproductive tracts. They trap and process ANTIGENS, and present them to T-CELLS, thereby stimulating CELL-MEDIATED IMMUNITY. They are different from the non-hematopoietic FOLLICULAR DENDRITIC CELLS, which have a similar morphology and immune system function, but with respect to humoral immunity (ANTIBODY PRODUCTION). Dendritic Cells, Interdigitating,Interdigitating Cells,Plasmacytoid Dendritic Cells,Veiled Cells,Dendritic Cells, Interstitial,Dendritic Cells, Plasmacytoid,Interdigitating Dendritic Cells,Interstitial Dendritic Cells,Cell, Dendritic,Cell, Interdigitating,Cell, Interdigitating Dendritic,Cell, Interstitial Dendritic,Cell, Plasmacytoid Dendritic,Cell, Veiled,Cells, Dendritic,Cells, Interdigitating,Cells, Interdigitating Dendritic,Cells, Interstitial Dendritic,Cells, Plasmacytoid Dendritic,Cells, Veiled,Dendritic Cell,Dendritic Cell, Interdigitating,Dendritic Cell, Interstitial,Dendritic Cell, Plasmacytoid,Interdigitating Cell,Interdigitating Dendritic Cell,Interstitial Dendritic Cell,Plasmacytoid Dendritic Cell,Veiled Cell
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015496 CD4-Positive T-Lymphocytes A critical subpopulation of T-lymphocytes involved in the induction of most immunological functions. The HIV virus has selective tropism for the T4 cell which expresses the CD4 phenotypic marker, a receptor for HIV. In fact, the key element in the profound immunosuppression seen in HIV infection is the depletion of this subset of T-lymphocytes. T4 Cells,T4 Lymphocytes,CD4-Positive Lymphocytes,CD4 Positive T Lymphocytes,CD4-Positive Lymphocyte,CD4-Positive T-Lymphocyte,Lymphocyte, CD4-Positive,Lymphocytes, CD4-Positive,T-Lymphocyte, CD4-Positive,T-Lymphocytes, CD4-Positive,T4 Cell,T4 Lymphocyte
D016176 T-Lymphocyte Subsets A classification of T-lymphocytes, especially into helper/inducer, suppressor/effector, and cytotoxic subsets, based on structurally or functionally different populations of cells. T-Cell Subset,T-Cell Subsets,T-Lymphocyte Subset,Subset, T-Cell,Subset, T-Lymphocyte,Subsets, T-Cell,Subsets, T-Lymphocyte,T Cell Subset,T Cell Subsets,T Lymphocyte Subset,T Lymphocyte Subsets
D053645 Interleukin-2 Receptor alpha Subunit A low affinity interleukin-2 receptor subunit that combines with the INTERLEUKIN-2 RECEPTOR BETA SUBUNIT and the INTERLEUKIN RECEPTOR COMMON GAMMA-CHAIN to form a high affinity receptor for INTERLEUKIN-2. Antigens, CD25,CD25 Antigens,Interleukin-2 Receptors alpha,Tac P55 Peptide,CD25 Antigen,IL-2Ralpha,Interleukin-2 Receptor alpha,Interleukin-2 Receptor alpha Chain,Interleukin-2Ralpha,alpha-subunit, Receptor, Interleukin-2,Antigen, CD25,IL 2Ralpha,Interleukin 2 Receptor alpha,Interleukin 2 Receptor alpha Chain,Interleukin 2 Receptor alpha Subunit,Interleukin 2 Receptors alpha,Interleukin 2Ralpha,Receptor alpha, Interleukin-2,Receptors alpha, Interleukin-2

Related Publications

Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
January 2004, International journal of molecular medicine,
Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
January 2012, British journal of biomedical science,
Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
March 2005, Human immunology,
Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
February 2000, Cellular immunology,
Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
April 2018, Thrombosis and haemostasis,
Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
April 2008, Immunology letters,
Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
November 2002, Transplantation proceedings,
Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
March 2016, Future oncology (London, England),
Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
July 2004, Blood,
Ji-Wei Liu, and Takashi Kawasaki, and Chikako Tomiyama, and Makoto Naito, and Dan-Xi Wu, and Jun Ma
September 2012, Journal of leukocyte biology,
Copied contents to your clipboard!