-transparent.png){kind=logo}
The relationship between molecular structure and the binding potential of steroids to receptor proteins was investigated. Twenty-four selected steroids were studied in minced incubations of rat prostate tissue. Measurements of the inhibitory effects of the steroids on the binding of tritiated 5alpha-dihydrotestosterone to the receptor proteins were obtained in the 100,000 times g dialysed supernatant and the purified nuclear component of the prostate cells. The steroids that achieved the highest degree of inhibition were those compounds that exhibited a generally planar geometric shape and were known to possess potent androgenic activity. Several of the compounds were shown to possess a higher degree of inhibition than that of testosterone or 5alpha-dihydrotestosterone. The data is further supportive of the two step theory that necessitates the complexing of the free steroids to the receptor proteins in the cytosol before transport to the nuclei. Evidence is also suggestive of the presence of 17-esterase activity. The inhibitory effect of the steroids apparently involves the binding to the intracellular receptors and is not related to the uptake of 5alpha-dihydrotestosterone into the cell.
R W Skinner, and
R V Pozderac, and
R E Counsell, and
P A Weinhold
August 1973,
Science (New York, N.Y.),
R W Skinner, and
R V Pozderac, and
R E Counsell, and
P A Weinhold
December 1973,
Endocrinologia japonica,
R W Skinner, and
R V Pozderac, and
R E Counsell, and
P A Weinhold
August 1973,
Endocrinologia japonica,
R W Skinner, and
R V Pozderac, and
R E Counsell, and
P A Weinhold
June 1979,
Urology,
R W Skinner, and
R V Pozderac, and
R E Counsell, and
P A Weinhold
August 1975,
Molecular and cellular endocrinology,
R W Skinner, and
R V Pozderac, and
R E Counsell, and
P A Weinhold
September 1974,
The Biochemical journal,
R W Skinner, and
R V Pozderac, and
R E Counsell, and
P A Weinhold
October 1975,
Endocrinologia japonica,
R W Skinner, and
R V Pozderac, and
R E Counsell, and
P A Weinhold
April 1977,
Journal of biochemistry,
R W Skinner, and
R V Pozderac, and
R E Counsell, and
P A Weinhold
November 1975,
Zentralblatt fur Bakteriologie, Parasitenkunde, Infektionskrankheiten und Hygiene. Erste Abteilung Originale. Reihe A: Medizinische Mikrobiologie und Parasitologie,
R W Skinner, and
R V Pozderac, and
R E Counsell, and
P A Weinhold
February 1979,
Endocrinologia japonica,
